Effects of Ginseng Peptides on Laxative in Mice
Objective: To study the moisturizing and laxative effects of ginseng peptides (GPs) on the constipation model of ICR mice, and provide theoretical basis for the further development and utilization of GPs and clinical adjuvant treatment of constipation. Methods: Sixty adult male ICR mice were randoml...
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The editorial department of Science and Technology of Food Industry
2025-01-01
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| Series: | Shipin gongye ke-ji |
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| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024010070 |
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| author | Qiannan WANG Wen YANG Tingfang XUE Jiaqi ZOU Tao FENG Lei YU Yunfeng BI Lina WANG |
| author_facet | Qiannan WANG Wen YANG Tingfang XUE Jiaqi ZOU Tao FENG Lei YU Yunfeng BI Lina WANG |
| author_sort | Qiannan WANG |
| collection | DOAJ |
| description | Objective: To study the moisturizing and laxative effects of ginseng peptides (GPs) on the constipation model of ICR mice, and provide theoretical basis for the further development and utilization of GPs and clinical adjuvant treatment of constipation. Methods: Sixty adult male ICR mice were randomly divided into 6 groups, they were normal group (NG), constipation group (CG), whey protein group (WPG), low-dose GPs group (LG), medium-dose GPs group (MG), high-dose GPs group (HG). Except NG, mouse constipation model was established using loperamide hydrochloride (LH). After 7 consecutive days of intervention with GPs, the small intestine peristalsis and defecation time, as well as pathological changes in the small intestine villus tissue of each group of mice were observed and compared. The improvement effect of GPs on mouse constipation was evaluated by detecting the content of brain gut peptide indicators in the serum of each group of mice, including substance P (SP) and vasoactive intestinal peptide (VIP). Results: Compared with the model group, the high, medium, and low dose groups of GPs significantly increased the small intestine ink advance rate in mice (P<0.01), which could alleviate the pathological damage of small intestine villi in constipated mice. Compared with the model group, the high-dose GPs group significantly shortened the first black stool excretion time (P<0.01), increased the number of fecal particles (P<0.05), and significantly increased fecal weight within 5 hours (P<0.01) in mice. The serum levels of substance P (SP) and vasoactive intestinal peptide (VIP) were significantly increased in the high and medium dose groups of GPs mice (P<0.01), while the low dose group of GPs increased the levels of brain intestinal peptide indicators SP and VIP in constipated mice (P<0.05). Conclusion: GPs has a significant laxative effect on a constipated mouse model, promoting small intestinal peristalsis, alleviating small intestinal villus damage, and promoting the expression of brain gut peptide markers SP and VIP in mice. |
| format | Article |
| id | doaj-art-d85941e31cea4ed696c0c72cd71e8c0b |
| institution | Kabale University |
| issn | 1002-0306 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
| record_format | Article |
| series | Shipin gongye ke-ji |
| spelling | doaj-art-d85941e31cea4ed696c0c72cd71e8c0b2025-01-10T06:49:31ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062025-01-0146231732310.13386/j.issn1002-0306.20240100702024010070-2Effects of Ginseng Peptides on Laxative in MiceQiannan WANG0Wen YANG1Tingfang XUE2Jiaqi ZOU3Tao FENG4Lei YU5Yunfeng BI6Lina WANG7College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaJilin Hongjiu Biotechnology Co., Ltd., Tonghua 135118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, ChinaCollege of Pharmacy, Jilin Medical College, Jilin 132013, ChinaObjective: To study the moisturizing and laxative effects of ginseng peptides (GPs) on the constipation model of ICR mice, and provide theoretical basis for the further development and utilization of GPs and clinical adjuvant treatment of constipation. Methods: Sixty adult male ICR mice were randomly divided into 6 groups, they were normal group (NG), constipation group (CG), whey protein group (WPG), low-dose GPs group (LG), medium-dose GPs group (MG), high-dose GPs group (HG). Except NG, mouse constipation model was established using loperamide hydrochloride (LH). After 7 consecutive days of intervention with GPs, the small intestine peristalsis and defecation time, as well as pathological changes in the small intestine villus tissue of each group of mice were observed and compared. The improvement effect of GPs on mouse constipation was evaluated by detecting the content of brain gut peptide indicators in the serum of each group of mice, including substance P (SP) and vasoactive intestinal peptide (VIP). Results: Compared with the model group, the high, medium, and low dose groups of GPs significantly increased the small intestine ink advance rate in mice (P<0.01), which could alleviate the pathological damage of small intestine villi in constipated mice. Compared with the model group, the high-dose GPs group significantly shortened the first black stool excretion time (P<0.01), increased the number of fecal particles (P<0.05), and significantly increased fecal weight within 5 hours (P<0.01) in mice. The serum levels of substance P (SP) and vasoactive intestinal peptide (VIP) were significantly increased in the high and medium dose groups of GPs mice (P<0.01), while the low dose group of GPs increased the levels of brain intestinal peptide indicators SP and VIP in constipated mice (P<0.05). Conclusion: GPs has a significant laxative effect on a constipated mouse model, promoting small intestinal peristalsis, alleviating small intestinal villus damage, and promoting the expression of brain gut peptide markers SP and VIP in mice.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024010070ginseng peptideslaxativeconstipationsubstance pvasoactive intestinal peptide |
| spellingShingle | Qiannan WANG Wen YANG Tingfang XUE Jiaqi ZOU Tao FENG Lei YU Yunfeng BI Lina WANG Effects of Ginseng Peptides on Laxative in Mice Shipin gongye ke-ji ginseng peptides laxative constipation substance p vasoactive intestinal peptide |
| title | Effects of Ginseng Peptides on Laxative in Mice |
| title_full | Effects of Ginseng Peptides on Laxative in Mice |
| title_fullStr | Effects of Ginseng Peptides on Laxative in Mice |
| title_full_unstemmed | Effects of Ginseng Peptides on Laxative in Mice |
| title_short | Effects of Ginseng Peptides on Laxative in Mice |
| title_sort | effects of ginseng peptides on laxative in mice |
| topic | ginseng peptides laxative constipation substance p vasoactive intestinal peptide |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024010070 |
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