Analysis of survival-related factors in patients with endometrial cancer using a Bayesian network model.
<h4>Background</h4>In recent years, remarkable progress has been made in the use of machine learning, especially in analyzing prognosis survival data. Traditional prediction models cannot identify interrelationships between factors, and the predictive accuracy is lower. This study aimed...
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| Format: | Article |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0314018 |
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| _version_ | 1846157770187866112 |
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| author | Huan Zhang Shan Zhao Pengzhong Lv |
| author_facet | Huan Zhang Shan Zhao Pengzhong Lv |
| author_sort | Huan Zhang |
| collection | DOAJ |
| description | <h4>Background</h4>In recent years, remarkable progress has been made in the use of machine learning, especially in analyzing prognosis survival data. Traditional prediction models cannot identify interrelationships between factors, and the predictive accuracy is lower. This study aimed to construct Bayesian network models using the tree augmented naïve algorithm in comparison with the Cox proportional hazards model.<h4>Methods</h4>A Bayesian network model and a Cox proportional hazards model were constructed to analyze the prognostic factors of endometrial cancer. In total, 618 original cases obtained from the Surveillance, Epidemiology, and End Results database were used to construct the Bayesian network model, which was compared with the traditional Cox proportional hazards model by analyzing prognostic factors. External validation was performed using a dataset from The First Affiliated Hospital of Shandong First Medical University.<h4>Results</h4>The predictive accuracy, area under the receiver operating characteristic curve, and concordance index for the Bayesian network model were 74.68%, 0.787, and 0.72, respectively, compared to 68.83%, 0.723, and 0.71, respectively, for the Cox proportional hazards model. Tumor size was the most important factor for predicting survival, followed by lymph node metastasis, distant metastasis, chemotherapy, lymph node resection, tumor stage, depth of invasion, tumor grade, histological type, age, primary tumor site, radiotherapy and surgical sequence, and radiotherapy.<h4>Conclusion</h4>The findings indicate that the Bayesian network model is preferable to the Cox proportional hazards model for predicting survival in patients with endometrial cancer. |
| format | Article |
| id | doaj-art-d854231fccd24114809d75cfeccb06be |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-d854231fccd24114809d75cfeccb06be2024-11-25T05:31:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011911e031401810.1371/journal.pone.0314018Analysis of survival-related factors in patients with endometrial cancer using a Bayesian network model.Huan ZhangShan ZhaoPengzhong Lv<h4>Background</h4>In recent years, remarkable progress has been made in the use of machine learning, especially in analyzing prognosis survival data. Traditional prediction models cannot identify interrelationships between factors, and the predictive accuracy is lower. This study aimed to construct Bayesian network models using the tree augmented naïve algorithm in comparison with the Cox proportional hazards model.<h4>Methods</h4>A Bayesian network model and a Cox proportional hazards model were constructed to analyze the prognostic factors of endometrial cancer. In total, 618 original cases obtained from the Surveillance, Epidemiology, and End Results database were used to construct the Bayesian network model, which was compared with the traditional Cox proportional hazards model by analyzing prognostic factors. External validation was performed using a dataset from The First Affiliated Hospital of Shandong First Medical University.<h4>Results</h4>The predictive accuracy, area under the receiver operating characteristic curve, and concordance index for the Bayesian network model were 74.68%, 0.787, and 0.72, respectively, compared to 68.83%, 0.723, and 0.71, respectively, for the Cox proportional hazards model. Tumor size was the most important factor for predicting survival, followed by lymph node metastasis, distant metastasis, chemotherapy, lymph node resection, tumor stage, depth of invasion, tumor grade, histological type, age, primary tumor site, radiotherapy and surgical sequence, and radiotherapy.<h4>Conclusion</h4>The findings indicate that the Bayesian network model is preferable to the Cox proportional hazards model for predicting survival in patients with endometrial cancer.https://doi.org/10.1371/journal.pone.0314018 |
| spellingShingle | Huan Zhang Shan Zhao Pengzhong Lv Analysis of survival-related factors in patients with endometrial cancer using a Bayesian network model. PLoS ONE |
| title | Analysis of survival-related factors in patients with endometrial cancer using a Bayesian network model. |
| title_full | Analysis of survival-related factors in patients with endometrial cancer using a Bayesian network model. |
| title_fullStr | Analysis of survival-related factors in patients with endometrial cancer using a Bayesian network model. |
| title_full_unstemmed | Analysis of survival-related factors in patients with endometrial cancer using a Bayesian network model. |
| title_short | Analysis of survival-related factors in patients with endometrial cancer using a Bayesian network model. |
| title_sort | analysis of survival related factors in patients with endometrial cancer using a bayesian network model |
| url | https://doi.org/10.1371/journal.pone.0314018 |
| work_keys_str_mv | AT huanzhang analysisofsurvivalrelatedfactorsinpatientswithendometrialcancerusingabayesiannetworkmodel AT shanzhao analysisofsurvivalrelatedfactorsinpatientswithendometrialcancerusingabayesiannetworkmodel AT pengzhonglv analysisofsurvivalrelatedfactorsinpatientswithendometrialcancerusingabayesiannetworkmodel |