The inhibitory effect of GsMTx4 on pain sensation during tooth movement in rats
Objective To investigate the inhibitory effect of GsMTx4 on pain sensation in rats during tooth movement, open field experiments and immunohistochemical staining by conducting. Methods Fifty-eight male SD rats aged 5-6 weeks were selected and a right maxillary tooth movement model was constructed. T...
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Editorial Office of Stomatology
2024-11-01
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| Series: | Kouqiang yixue |
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| author | WANG Ruofei, SHAO Lixin, LIU Xiaotong, ZHANG Miaomiao |
| author_facet | WANG Ruofei, SHAO Lixin, LIU Xiaotong, ZHANG Miaomiao |
| author_sort | WANG Ruofei, SHAO Lixin, LIU Xiaotong, ZHANG Miaomiao |
| collection | DOAJ |
| description | Objective To investigate the inhibitory effect of GsMTx4 on pain sensation in rats during tooth movement, open field experiments and immunohistochemical staining by conducting. Methods Fifty-eight male SD rats aged 5-6 weeks were selected and a right maxillary tooth movement model was constructed. The rats were randomly divided into two groups: group A(control group) and group B(GsMTx4 group). They were also divided into 5 subgroups according to 4 h, 1 d, 3 d, 5 d, and 7 d. The left maxillary of the rats in group A was used as group C(blank control group). The open-field test was used to evaluate the pain level of rats. Immunohistochemical staining was used to observe the expression of nerve growth factor(NGF) and calcitonin gene-related peptide(CGRP) in periodontal tissues. Results At 4 h, 1 d, and 3 d, the total distance traveled by rats in group B within 5 minutes in the open-field was higher than that of group A (P<0.05). At 4 h and 1 d, the percentage of time in the center of rats in group B was higher than that in group A(P<0.05). The expressions of NGF and CGRP in groups A and B were higher than those in group C on 1 d, 3 d, 5 d, and 7 d(P<0.05). The expression of NGF and CGRP in group B were lower than those in group A at 4 h, 1 d, and 3 d(P<0.05). Conclusion GsMTx4 can inhibit the expression of NGF and CGRP during tooth movement and relieve the pain caused by tooth movement. |
| format | Article |
| id | doaj-art-d849d538971d4c98880eb8bc5c9c8170 |
| institution | Kabale University |
| issn | 1003-9872 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Office of Stomatology |
| record_format | Article |
| series | Kouqiang yixue |
| spelling | doaj-art-d849d538971d4c98880eb8bc5c9c81702024-11-25T00:56:52ZzhoEditorial Office of StomatologyKouqiang yixue1003-98722024-11-01441181581910.13591/j.cnki.kqyx.2024.11.003The inhibitory effect of GsMTx4 on pain sensation during tooth movement in ratsWANG Ruofei, SHAO Lixin, LIU Xiaotong, ZHANG Miaomiao0Department of Orthodontics, First Affilated Hospital of Harbin Medical University, Harbin 150001, ChinaObjective To investigate the inhibitory effect of GsMTx4 on pain sensation in rats during tooth movement, open field experiments and immunohistochemical staining by conducting. Methods Fifty-eight male SD rats aged 5-6 weeks were selected and a right maxillary tooth movement model was constructed. The rats were randomly divided into two groups: group A(control group) and group B(GsMTx4 group). They were also divided into 5 subgroups according to 4 h, 1 d, 3 d, 5 d, and 7 d. The left maxillary of the rats in group A was used as group C(blank control group). The open-field test was used to evaluate the pain level of rats. Immunohistochemical staining was used to observe the expression of nerve growth factor(NGF) and calcitonin gene-related peptide(CGRP) in periodontal tissues. Results At 4 h, 1 d, and 3 d, the total distance traveled by rats in group B within 5 minutes in the open-field was higher than that of group A (P<0.05). At 4 h and 1 d, the percentage of time in the center of rats in group B was higher than that in group A(P<0.05). The expressions of NGF and CGRP in groups A and B were higher than those in group C on 1 d, 3 d, 5 d, and 7 d(P<0.05). The expression of NGF and CGRP in group B were lower than those in group A at 4 h, 1 d, and 3 d(P<0.05). Conclusion GsMTx4 can inhibit the expression of NGF and CGRP during tooth movement and relieve the pain caused by tooth movement.https://www.stomatology.cn/fileup/1003-9872/PDF/1731916758703-898605997.pdf|gsmtx4|orthodontic|pain|ngf|cgrp |
| spellingShingle | WANG Ruofei, SHAO Lixin, LIU Xiaotong, ZHANG Miaomiao The inhibitory effect of GsMTx4 on pain sensation during tooth movement in rats Kouqiang yixue |gsmtx4|orthodontic|pain|ngf|cgrp |
| title | The inhibitory effect of GsMTx4 on pain sensation during tooth movement in rats |
| title_full | The inhibitory effect of GsMTx4 on pain sensation during tooth movement in rats |
| title_fullStr | The inhibitory effect of GsMTx4 on pain sensation during tooth movement in rats |
| title_full_unstemmed | The inhibitory effect of GsMTx4 on pain sensation during tooth movement in rats |
| title_short | The inhibitory effect of GsMTx4 on pain sensation during tooth movement in rats |
| title_sort | inhibitory effect of gsmtx4 on pain sensation during tooth movement in rats |
| topic | |gsmtx4|orthodontic|pain|ngf|cgrp |
| url | https://www.stomatology.cn/fileup/1003-9872/PDF/1731916758703-898605997.pdf |
| work_keys_str_mv | AT wangruofeishaolixinliuxiaotongzhangmiaomiao theinhibitoryeffectofgsmtx4onpainsensationduringtoothmovementinrats AT wangruofeishaolixinliuxiaotongzhangmiaomiao inhibitoryeffectofgsmtx4onpainsensationduringtoothmovementinrats |