EFFICACY AND SAFETY OF THERAPY WITH ATORVASTATIN IN HIGH DOSES
Large epidemiological trails shown that hypercholesterolemia is one of the main risk factor of ischemic heart disease (IHD). Correction of the hypercholesterolemia with GmGKoA reductase inhibitors (statins) essentially reduces IHD morbidity and mortality. The lower serum level of low density lipopro...
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| Language: | English |
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/820 |
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| _version_ | 1849227826852528128 |
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| author | A. N. Meshkov |
| author_facet | A. N. Meshkov |
| author_sort | A. N. Meshkov |
| collection | DOAJ |
| description | Large epidemiological trails shown that hypercholesterolemia is one of the main risk factor of ischemic heart disease (IHD). Correction of the hypercholesterolemia with GmGKoA reductase inhibitors (statins) essentially reduces IHD morbidity and mortality. The lower serum level of low density lipoprotein is - the lower risk of cardiovascular diseases and their complications are. Efficacy and safety of atorvastatin therapy in high doses is discussed in patients with IHD and dyslipidemia. Atorvastatin in high doses is more effective than standard therapy for prevention of cardiovascular complications. Atorvastatin is also effective in patients with recurrent cardiovascular events. Atorvastatin in high doses is safe and well tolerated. Serious side effects due to atorvastatin use (myopathy and rhabdomyolysis) are very rare. Generic atorvastatin 80 mg OD in ATLANTIC study was effective and safe. However efficacy and safety of other atorvastatin generics in dose of 80 mg OD is not well studied and it is necessary further studies. |
| format | Article |
| id | doaj-art-d847ed8d646f4866ae8299fc9df6f7a6 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-d847ed8d646f4866ae8299fc9df6f7a62025-08-23T10:00:23ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-016219720010.20996/1819-6446-2010-6-2-197-200819EFFICACY AND SAFETY OF THERAPY WITH ATORVASTATIN IN HIGH DOSESA. N. Meshkov0Russian Cardiology Research and Production ComplexLarge epidemiological trails shown that hypercholesterolemia is one of the main risk factor of ischemic heart disease (IHD). Correction of the hypercholesterolemia with GmGKoA reductase inhibitors (statins) essentially reduces IHD morbidity and mortality. The lower serum level of low density lipoprotein is - the lower risk of cardiovascular diseases and their complications are. Efficacy and safety of atorvastatin therapy in high doses is discussed in patients with IHD and dyslipidemia. Atorvastatin in high doses is more effective than standard therapy for prevention of cardiovascular complications. Atorvastatin is also effective in patients with recurrent cardiovascular events. Atorvastatin in high doses is safe and well tolerated. Serious side effects due to atorvastatin use (myopathy and rhabdomyolysis) are very rare. Generic atorvastatin 80 mg OD in ATLANTIC study was effective and safe. However efficacy and safety of other atorvastatin generics in dose of 80 mg OD is not well studied and it is necessary further studies.https://www.rpcardio.online/jour/article/view/820hypercholesterolemiaischemic heart diseaseatorvastatin |
| spellingShingle | A. N. Meshkov EFFICACY AND SAFETY OF THERAPY WITH ATORVASTATIN IN HIGH DOSES Рациональная фармакотерапия в кардиологии hypercholesterolemia ischemic heart disease atorvastatin |
| title | EFFICACY AND SAFETY OF THERAPY WITH ATORVASTATIN IN HIGH DOSES |
| title_full | EFFICACY AND SAFETY OF THERAPY WITH ATORVASTATIN IN HIGH DOSES |
| title_fullStr | EFFICACY AND SAFETY OF THERAPY WITH ATORVASTATIN IN HIGH DOSES |
| title_full_unstemmed | EFFICACY AND SAFETY OF THERAPY WITH ATORVASTATIN IN HIGH DOSES |
| title_short | EFFICACY AND SAFETY OF THERAPY WITH ATORVASTATIN IN HIGH DOSES |
| title_sort | efficacy and safety of therapy with atorvastatin in high doses |
| topic | hypercholesterolemia ischemic heart disease atorvastatin |
| url | https://www.rpcardio.online/jour/article/view/820 |
| work_keys_str_mv | AT anmeshkov efficacyandsafetyoftherapywithatorvastatininhighdoses |