Bisindole Compounds—Synthesis and Medicinal Properties
The indole nucleus stands out as a pharmacophore, among other aromatic heterocyclic compounds with remarkable therapeutic properties, such as benzimidazole, pyridine, quinoline, benzothiazole, and others. Moreover, a series of recent studies refer to strategies for the synthesis of bisindole derivat...
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MDPI AG
2024-12-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/13/12/1212 |
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| author | Maria Marinescu |
| author_facet | Maria Marinescu |
| author_sort | Maria Marinescu |
| collection | DOAJ |
| description | The indole nucleus stands out as a pharmacophore, among other aromatic heterocyclic compounds with remarkable therapeutic properties, such as benzimidazole, pyridine, quinoline, benzothiazole, and others. Moreover, a series of recent studies refer to strategies for the synthesis of bisindole derivatives, with various medicinal properties, such as antimicrobial, antiviral, anticancer, anti-Alzheimer, anti-inflammatory, antioxidant, antidiabetic, etc. Also, a series of natural bisindole compounds are mentioned in the literature for their various biological properties and as a starting point in the synthesis of other related bisindoles. Drawing from these data, we have proposed in this review to provide an overview of the synthesis techniques and medicinal qualities of the bisindolic compounds that have been mentioned in recent literature from 2010 to 2024 as well as their numerous uses in the chemistry of materials, nanomaterials, dyes, polymers, and corrosion inhibitors. |
| format | Article |
| id | doaj-art-d81826ecb2ca42d78753e666b2715ba9 |
| institution | Kabale University |
| issn | 2079-6382 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-d81826ecb2ca42d78753e666b2715ba92024-12-27T14:06:23ZengMDPI AGAntibiotics2079-63822024-12-011312121210.3390/antibiotics13121212Bisindole Compounds—Synthesis and Medicinal PropertiesMaria Marinescu0Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, Soseaua Panduri, 030018 Bucharest, RomaniaThe indole nucleus stands out as a pharmacophore, among other aromatic heterocyclic compounds with remarkable therapeutic properties, such as benzimidazole, pyridine, quinoline, benzothiazole, and others. Moreover, a series of recent studies refer to strategies for the synthesis of bisindole derivatives, with various medicinal properties, such as antimicrobial, antiviral, anticancer, anti-Alzheimer, anti-inflammatory, antioxidant, antidiabetic, etc. Also, a series of natural bisindole compounds are mentioned in the literature for their various biological properties and as a starting point in the synthesis of other related bisindoles. Drawing from these data, we have proposed in this review to provide an overview of the synthesis techniques and medicinal qualities of the bisindolic compounds that have been mentioned in recent literature from 2010 to 2024 as well as their numerous uses in the chemistry of materials, nanomaterials, dyes, polymers, and corrosion inhibitors.https://www.mdpi.com/2079-6382/13/12/1212indolepharmacophoreantimicrobialantiviralpharmaceutical properties |
| spellingShingle | Maria Marinescu Bisindole Compounds—Synthesis and Medicinal Properties Antibiotics indole pharmacophore antimicrobial antiviral pharmaceutical properties |
| title | Bisindole Compounds—Synthesis and Medicinal Properties |
| title_full | Bisindole Compounds—Synthesis and Medicinal Properties |
| title_fullStr | Bisindole Compounds—Synthesis and Medicinal Properties |
| title_full_unstemmed | Bisindole Compounds—Synthesis and Medicinal Properties |
| title_short | Bisindole Compounds—Synthesis and Medicinal Properties |
| title_sort | bisindole compounds synthesis and medicinal properties |
| topic | indole pharmacophore antimicrobial antiviral pharmaceutical properties |
| url | https://www.mdpi.com/2079-6382/13/12/1212 |
| work_keys_str_mv | AT mariamarinescu bisindolecompoundssynthesisandmedicinalproperties |