VON WILLEBRAND FACTOR, ANGIODYSPLASIA AND ANGIOGENESIS
The large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes. We recently described a new role for VWF in controlli...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2013-09-01
|
| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/422 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846098302321295360 |
|---|---|
| author | Anna M. Randi Mike A Laffan Richard D. Starke |
| author_facet | Anna M. Randi Mike A Laffan Richard D. Starke |
| author_sort | Anna M. Randi |
| collection | DOAJ |
| description | The large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes. We recently described a new role for VWF in controlling angiogenesis, which may have significant clinical implications for patients with Von Willebrand disease (VWD), a genetic or acquired condition caused by the deficiency or dysfunction of VWF. VWD can be associated with angiodysplasia, a condition of degenerative blood vessels often present in the gastrointestinal tract, linked to dysregulated angiogenesis. Angiodysplasia can cause severe intractable bleeding, often refractory to conventional VWD treatments. In this review summarise the evidence showing that VWF controls angiogenesis, and review the angiogenic pathways which have been implicated in this process. We discuss the possible mechanisms though which VWF regulates angiopoietin-2 (Ang-2) and integrin αvβ3, leading to signalling through vascular endothelial growth factor receptor-2 (VEGFR2), one of the most potent activators of angiogenesis. We also review the evidence that links VWF with angiodysplasia, and how the newly identified function of VWF in controlling angiogenesis may pave the way for the development of novel therapies for the treatment of angiodysplasia in congenital VWD and in acquired conditions such as Heyde syndrome. |
| format | Article |
| id | doaj-art-d7f22339637b450393b5fa1a87d41063 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2013-09-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-d7f22339637b450393b5fa1a87d410632025-01-02T01:24:05ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062013-09-0151e2013060e201306010.4084/mjhid.2013.060314VON WILLEBRAND FACTOR, ANGIODYSPLASIA AND ANGIOGENESISAnna M. Randi0Mike A Laffan1Richard D. Starke2Imperial College London, NHLI Vascular Sciences, Hammersmith Hospital, Du Cane Rd, LondonDepartment of Haematology, Hammersmith Campus, Imperial College London, LondonImperial College London, NHLI Vascular Sciences, Hammersmith Hospital, Du Cane Rd, LondonThe large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes. We recently described a new role for VWF in controlling angiogenesis, which may have significant clinical implications for patients with Von Willebrand disease (VWD), a genetic or acquired condition caused by the deficiency or dysfunction of VWF. VWD can be associated with angiodysplasia, a condition of degenerative blood vessels often present in the gastrointestinal tract, linked to dysregulated angiogenesis. Angiodysplasia can cause severe intractable bleeding, often refractory to conventional VWD treatments. In this review summarise the evidence showing that VWF controls angiogenesis, and review the angiogenic pathways which have been implicated in this process. We discuss the possible mechanisms though which VWF regulates angiopoietin-2 (Ang-2) and integrin αvβ3, leading to signalling through vascular endothelial growth factor receptor-2 (VEGFR2), one of the most potent activators of angiogenesis. We also review the evidence that links VWF with angiodysplasia, and how the newly identified function of VWF in controlling angiogenesis may pave the way for the development of novel therapies for the treatment of angiodysplasia in congenital VWD and in acquired conditions such as Heyde syndrome.http://www.mjhid.org/index.php/mjhid/article/view/422Willebrandangiogenesisendotheliumangiodysplasiagastrointestinal bleeding |
| spellingShingle | Anna M. Randi Mike A Laffan Richard D. Starke VON WILLEBRAND FACTOR, ANGIODYSPLASIA AND ANGIOGENESIS Mediterranean Journal of Hematology and Infectious Diseases Willebrand angiogenesis endothelium angiodysplasia gastrointestinal bleeding |
| title | VON WILLEBRAND FACTOR, ANGIODYSPLASIA AND ANGIOGENESIS |
| title_full | VON WILLEBRAND FACTOR, ANGIODYSPLASIA AND ANGIOGENESIS |
| title_fullStr | VON WILLEBRAND FACTOR, ANGIODYSPLASIA AND ANGIOGENESIS |
| title_full_unstemmed | VON WILLEBRAND FACTOR, ANGIODYSPLASIA AND ANGIOGENESIS |
| title_short | VON WILLEBRAND FACTOR, ANGIODYSPLASIA AND ANGIOGENESIS |
| title_sort | von willebrand factor angiodysplasia and angiogenesis |
| topic | Willebrand angiogenesis endothelium angiodysplasia gastrointestinal bleeding |
| url | http://www.mjhid.org/index.php/mjhid/article/view/422 |
| work_keys_str_mv | AT annamrandi vonwillebrandfactorangiodysplasiaandangiogenesis AT mikealaffan vonwillebrandfactorangiodysplasiaandangiogenesis AT richarddstarke vonwillebrandfactorangiodysplasiaandangiogenesis |