Electrophysiological Evidence on Mirror Therapy for Promoting Perceptuo-Motor Processes in Stroke Patients
Mirror therapy is proposed to enhance post-stroke awareness of the affected limb and mental ability, but convincing evidence on the perceptuo-motor processes is insufficient. In this study, we aimed to investigate the longitudinal effect of mirror therapy on limb perception and early motor processes...
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| Format: | Article |
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IEEE
2024-01-01
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| Series: | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
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| Online Access: | https://ieeexplore.ieee.org/document/10759844/ |
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| author | Li Ding Dan Wang Chengcheng Wu Xu Wang Jinyang Zhuang Xiaoli Guo Jie Jia |
| author_facet | Li Ding Dan Wang Chengcheng Wu Xu Wang Jinyang Zhuang Xiaoli Guo Jie Jia |
| author_sort | Li Ding |
| collection | DOAJ |
| description | Mirror therapy is proposed to enhance post-stroke awareness of the affected limb and mental ability, but convincing evidence on the perceptuo-motor processes is insufficient. In this study, we aimed to investigate the longitudinal effect of mirror therapy on limb perception and early motor processes in stroke patients using the hand mental rotation (HMR) task with both behavioral and electrophysiological evidence. Fifty stroke patients were randomly assigned to a mirror therapy group (MG, N =25) or a conventional treatment group (CG, N =25). Before and after 4-week intervention, the HMR task was performed, and its behavioral performance and EEG characteristics were measured and correlated with clinical outcomes. Behavioral analysis showed that enhanced accuracy of the HMR task, correlating with greater improvement in upper extremity motor function, was only observed in the MG. The ERD/ERS and brain network analysis revealed significant group differences in brain activation and local network metrics in the ipsilesional hemisphere during the preparation and execution of mental rotation while processing the affected hand stimuli. Specifically, the MG showed enhanced ipsilesional parietal ERD in the <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula> (8-13 Hz) and <inline-formula> <tex-math notation="LaTeX">$\beta 1$ </tex-math></inline-formula> (13-20 Hz) bands, along with increased ipsilesional centroparietal nodal strength and betweenness centrality, which were cross-correlated. The results indicate the potential of long-term mirror therapy for promoting perceptuo-motor processes, facilitating visuospatial perception, and improving motor preparation and mental ability of the affected limb, thereby contributing to post-stroke recovery. |
| format | Article |
| id | doaj-art-d7dc6fa2bd544c51b04884c4a05aa9ee |
| institution | Kabale University |
| issn | 1534-4320 1558-0210 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IEEE |
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| series | IEEE Transactions on Neural Systems and Rehabilitation Engineering |
| spelling | doaj-art-d7dc6fa2bd544c51b04884c4a05aa9ee2024-11-28T00:00:07ZengIEEEIEEE Transactions on Neural Systems and Rehabilitation Engineering1534-43201558-02102024-01-01324197420610.1109/TNSRE.2024.350365710759844Electrophysiological Evidence on Mirror Therapy for Promoting Perceptuo-Motor Processes in Stroke PatientsLi Ding0https://orcid.org/0000-0002-6067-4483Dan Wang1Chengcheng Wu2Xu Wang3Jinyang Zhuang4Xiaoli Guo5https://orcid.org/0000-0002-6346-1846Jie Jia6https://orcid.org/0000-0002-4516-4629Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, ChinaSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, ChinaSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Rehabilitation Medicine and the National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, ChinaMirror therapy is proposed to enhance post-stroke awareness of the affected limb and mental ability, but convincing evidence on the perceptuo-motor processes is insufficient. In this study, we aimed to investigate the longitudinal effect of mirror therapy on limb perception and early motor processes in stroke patients using the hand mental rotation (HMR) task with both behavioral and electrophysiological evidence. Fifty stroke patients were randomly assigned to a mirror therapy group (MG, N =25) or a conventional treatment group (CG, N =25). Before and after 4-week intervention, the HMR task was performed, and its behavioral performance and EEG characteristics were measured and correlated with clinical outcomes. Behavioral analysis showed that enhanced accuracy of the HMR task, correlating with greater improvement in upper extremity motor function, was only observed in the MG. The ERD/ERS and brain network analysis revealed significant group differences in brain activation and local network metrics in the ipsilesional hemisphere during the preparation and execution of mental rotation while processing the affected hand stimuli. Specifically, the MG showed enhanced ipsilesional parietal ERD in the <inline-formula> <tex-math notation="LaTeX">$\alpha $ </tex-math></inline-formula> (8-13 Hz) and <inline-formula> <tex-math notation="LaTeX">$\beta 1$ </tex-math></inline-formula> (13-20 Hz) bands, along with increased ipsilesional centroparietal nodal strength and betweenness centrality, which were cross-correlated. The results indicate the potential of long-term mirror therapy for promoting perceptuo-motor processes, facilitating visuospatial perception, and improving motor preparation and mental ability of the affected limb, thereby contributing to post-stroke recovery.https://ieeexplore.ieee.org/document/10759844/Mirror therapyhand mental rotationperceptionperceptuo-motor processesbrain networkelectroencephalography |
| spellingShingle | Li Ding Dan Wang Chengcheng Wu Xu Wang Jinyang Zhuang Xiaoli Guo Jie Jia Electrophysiological Evidence on Mirror Therapy for Promoting Perceptuo-Motor Processes in Stroke Patients IEEE Transactions on Neural Systems and Rehabilitation Engineering Mirror therapy hand mental rotation perception perceptuo-motor processes brain network electroencephalography |
| title | Electrophysiological Evidence on Mirror Therapy for Promoting Perceptuo-Motor Processes in Stroke Patients |
| title_full | Electrophysiological Evidence on Mirror Therapy for Promoting Perceptuo-Motor Processes in Stroke Patients |
| title_fullStr | Electrophysiological Evidence on Mirror Therapy for Promoting Perceptuo-Motor Processes in Stroke Patients |
| title_full_unstemmed | Electrophysiological Evidence on Mirror Therapy for Promoting Perceptuo-Motor Processes in Stroke Patients |
| title_short | Electrophysiological Evidence on Mirror Therapy for Promoting Perceptuo-Motor Processes in Stroke Patients |
| title_sort | electrophysiological evidence on mirror therapy for promoting perceptuo motor processes in stroke patients |
| topic | Mirror therapy hand mental rotation perception perceptuo-motor processes brain network electroencephalography |
| url | https://ieeexplore.ieee.org/document/10759844/ |
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