In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) study
Objective: Progress in best medical treatment have made identification of best candidates for carotid surgery more difficult. New diagnostic modalities could be helpful in this perspective. Microwaves (MWs) can quantify dielectric properties (complex relative permittivity) of biological tissues and...
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| Language: | English |
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Elsevier
2024-01-01
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| Series: | JVS - Vascular Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266635032300086X |
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| author | Rania Shahbaz, PhD Etienne Charpentier, MD Maharajah Ponnaiah, PhD Frédérique Deshours, PhD Hamid Kokabi, PhD Isabelle Brochériou, MD, PhD Gilles Le Naour, PhD Alban Redheuil, MD, PhD Fabien Koskas, MD, PhD Jean-Michel Davaine, MD, PhD |
| author_facet | Rania Shahbaz, PhD Etienne Charpentier, MD Maharajah Ponnaiah, PhD Frédérique Deshours, PhD Hamid Kokabi, PhD Isabelle Brochériou, MD, PhD Gilles Le Naour, PhD Alban Redheuil, MD, PhD Fabien Koskas, MD, PhD Jean-Michel Davaine, MD, PhD |
| author_sort | Rania Shahbaz, PhD |
| collection | DOAJ |
| description | Objective: Progress in best medical treatment have made identification of best candidates for carotid surgery more difficult. New diagnostic modalities could be helpful in this perspective. Microwaves (MWs) can quantify dielectric properties (complex relative permittivity) of biological tissues and MW technology has emerged as a promising field of research for distinguishing abnormal tissues from healthy ones. We here evaluated the ability of a dedicated MW sensor developed in our laboratory to identify vulnerable carotid lesions. Methods: We included 50 carotid lesions in this study. The plaques were analyzed and classified preoperatively by ultrasound (US) examination, computed tomography angiography and tested postoperatively using a MW sensor. Histopathological analysis was used as a gold standard to separate vulnerable plaques (VPs) from nonvulnerable plaques (NVPs). Results: VPs were more frequently types 2 or 3 plaques (on US examination), had a greater proportion of low (<60 Hounsfield unit) and moderate (60-130 Hounsfield unit) attenuation components (computed tomography angiography) and displayed higher dielectric constant values (MW) than NVPs, which had an opposite profile. NVPs were more frequently asymptomatic plaques compared with VPs (P = .035). Multivariate analysis showed that US examination and MW identified VPs with a sensitivity of 77% and a specificity of 76% (cutoff value, –0.045; area under the curve, 0.848; P < .0001). Conclusions: We found that the presence of types 2 to 3 (on US examination) and high dielectric constant plaques in vitro was highly indicative of a VP based on histological analysis. Further studies are needed to determine the potential of MW to identify the most dangerous asymptomatic carotid lesions. |
| format | Article |
| id | doaj-art-d79fef0e036c4e89a8a566436e15f2c4 |
| institution | Kabale University |
| issn | 2666-3503 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JVS - Vascular Science |
| spelling | doaj-art-d79fef0e036c4e89a8a566436e15f2c42024-12-26T08:57:39ZengElsevierJVS - Vascular Science2666-35032024-01-015100182In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) studyRania Shahbaz, PhD0Etienne Charpentier, MD1Maharajah Ponnaiah, PhD2Frédérique Deshours, PhD3Hamid Kokabi, PhD4Isabelle Brochériou, MD, PhD5Gilles Le Naour, PhD6Alban Redheuil, MD, PhD7Fabien Koskas, MD, PhD8Jean-Michel Davaine, MD, PhD9Sorbonne Université, CNRS UMR8507, Laboratoire Génie Électrique et Électronique de Paris (GeePs), Paris, FranceSorbonne Université, Unité d'imagerie cardiovasculaire et thoracique, Hôpital La Pitié Salpêtrière (AP-HP), Laboratoire d’Imagerie Biomédicale, INSERM, CNRS, Institute of Cardiometabolism and Nutrition, Paris, FranceIHU ICAN, Foundation for Innovation in Cardiometabolism and Nutrition, Pitié Salpêtrière Hospital, Paris, FranceSorbonne Université, CNRS UMR8507, Laboratoire Génie Électrique et Électronique de Paris (GeePs), Paris, FranceSorbonne Université, CNRS UMR8507, Laboratoire Génie Électrique et Électronique de Paris (GeePs), Paris, FranceMedicine Faculty, Sorbonne Université, Paris, FranceSorbonne Université, CNRS UMR8507, Laboratoire Génie Électrique et Électronique de Paris (GeePs), Paris, FranceSorbonne Université, Unité d'imagerie cardiovasculaire et thoracique, Hôpital La Pitié Salpêtrière (AP-HP), Laboratoire d’Imagerie Biomédicale, INSERM, CNRS, Institute of Cardiometabolism and Nutrition, Paris, FranceDepartment of Vascular and Endovascular Surgery, Pitié-Salpêtrière University Hospital, Paris, FranceMedicine Faculty, Sorbonne Université, Paris, France; Department of Vascular and Endovascular Surgery, Pitié-Salpêtrière University Hospital, Paris, France; Correspondence: Jean-Michel Davaine, MD, PhD, Department of Vascular and Endovascular Surgery, Sorbonne Université, Pitie-Salpêtrière University Hospital, 47-83 Bd de l’Hôpital, Paris, FranceObjective: Progress in best medical treatment have made identification of best candidates for carotid surgery more difficult. New diagnostic modalities could be helpful in this perspective. Microwaves (MWs) can quantify dielectric properties (complex relative permittivity) of biological tissues and MW technology has emerged as a promising field of research for distinguishing abnormal tissues from healthy ones. We here evaluated the ability of a dedicated MW sensor developed in our laboratory to identify vulnerable carotid lesions. Methods: We included 50 carotid lesions in this study. The plaques were analyzed and classified preoperatively by ultrasound (US) examination, computed tomography angiography and tested postoperatively using a MW sensor. Histopathological analysis was used as a gold standard to separate vulnerable plaques (VPs) from nonvulnerable plaques (NVPs). Results: VPs were more frequently types 2 or 3 plaques (on US examination), had a greater proportion of low (<60 Hounsfield unit) and moderate (60-130 Hounsfield unit) attenuation components (computed tomography angiography) and displayed higher dielectric constant values (MW) than NVPs, which had an opposite profile. NVPs were more frequently asymptomatic plaques compared with VPs (P = .035). Multivariate analysis showed that US examination and MW identified VPs with a sensitivity of 77% and a specificity of 76% (cutoff value, –0.045; area under the curve, 0.848; P < .0001). Conclusions: We found that the presence of types 2 to 3 (on US examination) and high dielectric constant plaques in vitro was highly indicative of a VP based on histological analysis. Further studies are needed to determine the potential of MW to identify the most dangerous asymptomatic carotid lesions.http://www.sciencedirect.com/science/article/pii/S266635032300086XCarotid plaque stabilityStrokeMicrowaveDuplex USRisk assessment |
| spellingShingle | Rania Shahbaz, PhD Etienne Charpentier, MD Maharajah Ponnaiah, PhD Frédérique Deshours, PhD Hamid Kokabi, PhD Isabelle Brochériou, MD, PhD Gilles Le Naour, PhD Alban Redheuil, MD, PhD Fabien Koskas, MD, PhD Jean-Michel Davaine, MD, PhD In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) study JVS - Vascular Science Carotid plaque stability Stroke Microwave Duplex US Risk assessment |
| title | In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) study |
| title_full | In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) study |
| title_fullStr | In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) study |
| title_full_unstemmed | In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) study |
| title_short | In vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques: Correlation with histology, Duplex ultrasound examination, and computed tomography scanner: The Imaging and Microwave Phenotyping Assessment of Carotid stenosis Threat (IMPACT) study |
| title_sort | in vitro analysis of carotid lesions using a preliminary microwave sensor to detect vulnerable plaques correlation with histology duplex ultrasound examination and computed tomography scanner the imaging and microwave phenotyping assessment of carotid stenosis threat impact study |
| topic | Carotid plaque stability Stroke Microwave Duplex US Risk assessment |
| url | http://www.sciencedirect.com/science/article/pii/S266635032300086X |
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