The Correlation between Serum Levels of Progranulin and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary Disease
Back ground: the Chronic Obstructive Pulmonary Disease (COPD) is a chronic Inflammatory disease of the airways and/ or parenchyma usually characterized by progressive irreversible airflow with accompanying respiratory symptoms like dyspnea, cough, production of sputum, and/or exacerbations. The pat...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine, University of Kufa
2024-06-01
|
| Series: | مجلة الكوفة الطبية |
| Subjects: | |
| Online Access: | https://journal.uokufa.edu.iq/index.php/kmj/article/view/15052 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846121536136675328 |
|---|---|
| author | Fatima Ali Abdulwahed Alkyoon Falah Mahdi Dananah |
| author_facet | Fatima Ali Abdulwahed Alkyoon Falah Mahdi Dananah |
| author_sort | Fatima Ali Abdulwahed Alkyoon |
| collection | DOAJ |
| description |
Back ground: the Chronic Obstructive Pulmonary Disease (COPD) is a chronic Inflammatory disease of the airways and/ or parenchyma usually characterized by progressive irreversible airflow with accompanying respiratory symptoms like dyspnea, cough, production of sputum, and/or exacerbations. The pathophysiology Of COPD involves bronchitis and /or emphysema, the effect of inflammation occurs in the lung and also have systemic effect, most common causes is tobacco smoking, occupational pollution, indoor pollution. Progranulin (PGRN) is defined as precursor of pleiotropic glycosylated protein, it has significant role in process of inflammation, angiogenesis, neoplasia, cell development, cell cycle, embryogenesis, wound healing, modification of autoimmune process, highly found in several type of cells like respiratory epithelial cells. Objective: The aim is to study relationship between serum level of PGRN and inflammatory markers in COPD patients. Material and method: A case control study composed of 40 patients with COPD and 45 controls, demographic characteristic, pulmonary function test, blood investigation include CRP-titer, WBC and plasma PGRN were measured and made comparison of data in cases with controls, data collected were statically analysis by SPSS. Result: The study showed that, there was no significant correlation between serum progranulin level, WBC and C-Reactive Protein titer in COPD patients (P value >0.05). Conclusions: It was concluded that PGRN level in COPD patients don’t correlate with CRP titer level or with WBC.
|
| format | Article |
| id | doaj-art-d798ff58f1544b0497178f4f4bdbb6cc |
| institution | Kabale University |
| issn | 1993-517X 2709-4464 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Faculty of Medicine, University of Kufa |
| record_format | Article |
| series | مجلة الكوفة الطبية |
| spelling | doaj-art-d798ff58f1544b0497178f4f4bdbb6cc2024-12-16T00:27:04ZengFaculty of Medicine, University of Kufaمجلة الكوفة الطبية1993-517X2709-44642024-06-0120110.36330/kmj.v20i1.15052The Correlation between Serum Levels of Progranulin and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary DiseaseFatima Ali Abdulwahed Alkyoon0Falah Mahdi Dananah1University of Kufa, Faculty of medicine, Department Medical PhysiologyUniversity of Kufa, Faculty of medicine, Department Medical Physiology Back ground: the Chronic Obstructive Pulmonary Disease (COPD) is a chronic Inflammatory disease of the airways and/ or parenchyma usually characterized by progressive irreversible airflow with accompanying respiratory symptoms like dyspnea, cough, production of sputum, and/or exacerbations. The pathophysiology Of COPD involves bronchitis and /or emphysema, the effect of inflammation occurs in the lung and also have systemic effect, most common causes is tobacco smoking, occupational pollution, indoor pollution. Progranulin (PGRN) is defined as precursor of pleiotropic glycosylated protein, it has significant role in process of inflammation, angiogenesis, neoplasia, cell development, cell cycle, embryogenesis, wound healing, modification of autoimmune process, highly found in several type of cells like respiratory epithelial cells. Objective: The aim is to study relationship between serum level of PGRN and inflammatory markers in COPD patients. Material and method: A case control study composed of 40 patients with COPD and 45 controls, demographic characteristic, pulmonary function test, blood investigation include CRP-titer, WBC and plasma PGRN were measured and made comparison of data in cases with controls, data collected were statically analysis by SPSS. Result: The study showed that, there was no significant correlation between serum progranulin level, WBC and C-Reactive Protein titer in COPD patients (P value >0.05). Conclusions: It was concluded that PGRN level in COPD patients don’t correlate with CRP titer level or with WBC. https://journal.uokufa.edu.iq/index.php/kmj/article/view/15052Chronic obstructive pulmonary diseaseProgranulinC-Reactive ProteinSpirometry, |
| spellingShingle | Fatima Ali Abdulwahed Alkyoon Falah Mahdi Dananah The Correlation between Serum Levels of Progranulin and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary Disease مجلة الكوفة الطبية Chronic obstructive pulmonary disease Progranulin C-Reactive Protein Spirometry, |
| title | The Correlation between Serum Levels of Progranulin and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary Disease |
| title_full | The Correlation between Serum Levels of Progranulin and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary Disease |
| title_fullStr | The Correlation between Serum Levels of Progranulin and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | The Correlation between Serum Levels of Progranulin and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary Disease |
| title_short | The Correlation between Serum Levels of Progranulin and Inflammatory Markers in Patients with Chronic Obstructive Pulmonary Disease |
| title_sort | correlation between serum levels of progranulin and inflammatory markers in patients with chronic obstructive pulmonary disease |
| topic | Chronic obstructive pulmonary disease Progranulin C-Reactive Protein Spirometry, |
| url | https://journal.uokufa.edu.iq/index.php/kmj/article/view/15052 |
| work_keys_str_mv | AT fatimaaliabdulwahedalkyoon thecorrelationbetweenserumlevelsofprogranulinandinflammatorymarkersinpatientswithchronicobstructivepulmonarydisease AT falahmahdidananah thecorrelationbetweenserumlevelsofprogranulinandinflammatorymarkersinpatientswithchronicobstructivepulmonarydisease AT fatimaaliabdulwahedalkyoon correlationbetweenserumlevelsofprogranulinandinflammatorymarkersinpatientswithchronicobstructivepulmonarydisease AT falahmahdidananah correlationbetweenserumlevelsofprogranulinandinflammatorymarkersinpatientswithchronicobstructivepulmonarydisease |