Green Synthesis of Antimicrobial Silver Nanoparticles (AgNPs) from the Mucus of the Garden Snail <i>Cornu aspersum</i>

Green Synthesis of Antimicrobial Silver Nanoparticles (AgNPs) from the Mucus of the Garden Snail <i>Cornu aspersum</i>

The green synthesis of metal nanoparticles, mediated by extracts from various biological sources, leads to the formation of nanoparticles with unique characteristics and potential biomedical applications. In this study, a fraction of the mucus from the snail <i>Cornu aspersum</i> with MW...

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Main Authors: Maria Todorova, Ventsislava Petrova, Bogdan Ranguelov, Georgy Avdeev, Lyudmila Velkova, Stela Atanasova-Vladimirova, Emiliya Pisareva, Chavdar Tankov, Anna Tomova, Aleksandar Dolashki, Pavlina Dolashka
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Molecules
Subjects:
antimicrobial activity
snail <i>Cornu aspersum</i>
ascorbic acid
silver nanoparticles
Online Access:https://www.mdpi.com/1420-3049/30/10/2150
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Summary:The green synthesis of metal nanoparticles, mediated by extracts from various biological sources, leads to the formation of nanoparticles with unique characteristics and potential biomedical applications. In this study, a fraction of the mucus from the snail <i>Cornu aspersum</i> with MW > 20 kDa was used as a bioreducing and biostabilizing agent to obtain silver nanoparticles (AgNPs) in different pH media (pH 1.5, 3.5, and 7.0). The AgNPs were characterized using UV-visible spectroscopy, SEM, TEM, XRD, and FTIR. The synthesis at pH 1.5 and pH 3.5 in the presence of two reducing agents (i.e., the <i>C. aspersum</i> mucus fraction with MW > 20 kDa and ascorbic acid [AsA]) resulted in the formation of well-formed spherical nanoparticles (NPs) with larger sizes (20–80 nm) than the NPs obtained at pH 7.0 (20–60 nm) in the presence of only one reducing agent. Furthermore, the biosynthesized AgNPs significantly inhibited the growth of medically significant pathogens such as Gram-positive (<i>Bacillus subtilis</i> NBIMCC2353, <i>Bacillus spizizenii</i> ATCC 6633, <i>Staphylococcus aureus</i> ATCC 6538, and <i>Listeria innocua</i> NBIMCC8755) and Gram-negative (<i>Escherichia coli</i> ATCC8739, <i>Salmonella enteitidis</i> NBIMCC8691, <i>Salmonella typhimurium</i> ATCC 14028, <i>Stenotrophomonas maltophilia</i> ATCC 17666) bacteria compared to output mucus.
ISSN:1420-3049

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