The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies
Abstract Neurodegenerative disorders encompass a group of age‐related conditions characterized by the gradual decline in both the structure and functionality of the central nervous system (CNS). RNA modifications, arising from the epitranscriptome or RNA‐modifying protein mutations, have recently be...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2024-12-01
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| Series: | Ibrain |
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| Online Access: | https://doi.org/10.1002/ibra.12183 |
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| author | Muhammad Abu Talha Safdar Hashmi Hooriya Fatima Sadia Ahmad Amna Rehman Fiza Safdar |
| author_facet | Muhammad Abu Talha Safdar Hashmi Hooriya Fatima Sadia Ahmad Amna Rehman Fiza Safdar |
| author_sort | Muhammad Abu Talha Safdar Hashmi |
| collection | DOAJ |
| description | Abstract Neurodegenerative disorders encompass a group of age‐related conditions characterized by the gradual decline in both the structure and functionality of the central nervous system (CNS). RNA modifications, arising from the epitranscriptome or RNA‐modifying protein mutations, have recently been observed to contribute significantly to neurodegenerative disorders. Specific modifications like N6‐methyladenine (m6A), N1‐methyladenine (m1A), 5‐methylcytosine (m5C), pseudouridine and adenosine‐to‐inosine (A‐to‐I) play key roles, with their regulators serving as crucial therapeutic targets. These epitranscriptomic changes intricately control gene expression, influencing cellular functions and contributing to disease pathology. Dysregulation of RNA metabolism, affecting mRNA processing and noncoding RNA biogenesis, is a central factor in these diseases. This review underscores the complex relationship between RNA modifications and neurodegenerative disorders, emphasizing the influence of RNA modification and the epitranscriptome, exploring the function of RNA modification enzymes in neurodegenerative processes, investigating the functional consequences of RNA modifications within neurodegenerative pathways, and evaluating the potential therapeutic advancements derived from assessing the epitranscriptome. |
| format | Article |
| id | doaj-art-d76abd101cb24cf6b3e776b7205622e6 |
| institution | Kabale University |
| issn | 2313-1934 2769-2795 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Ibrain |
| spelling | doaj-art-d76abd101cb24cf6b3e776b7205622e62024-12-17T03:11:26ZengWiley-VCHIbrain2313-19342769-27952024-12-0110439542610.1002/ibra.12183The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategiesMuhammad Abu Talha Safdar Hashmi0Hooriya Fatima1Sadia Ahmad2Amna Rehman3Fiza Safdar4Department of Zoology University of Central Punjab Lahore PakistanInstitute of Zoology University of Punjab Lahore PakistanInstitute of Zoology University of Punjab Lahore PakistanInstitute of Zoology University of Punjab Lahore PakistanDepartment of Biochemistry University of Narowal Narowal PakistanAbstract Neurodegenerative disorders encompass a group of age‐related conditions characterized by the gradual decline in both the structure and functionality of the central nervous system (CNS). RNA modifications, arising from the epitranscriptome or RNA‐modifying protein mutations, have recently been observed to contribute significantly to neurodegenerative disorders. Specific modifications like N6‐methyladenine (m6A), N1‐methyladenine (m1A), 5‐methylcytosine (m5C), pseudouridine and adenosine‐to‐inosine (A‐to‐I) play key roles, with their regulators serving as crucial therapeutic targets. These epitranscriptomic changes intricately control gene expression, influencing cellular functions and contributing to disease pathology. Dysregulation of RNA metabolism, affecting mRNA processing and noncoding RNA biogenesis, is a central factor in these diseases. This review underscores the complex relationship between RNA modifications and neurodegenerative disorders, emphasizing the influence of RNA modification and the epitranscriptome, exploring the function of RNA modification enzymes in neurodegenerative processes, investigating the functional consequences of RNA modifications within neurodegenerative pathways, and evaluating the potential therapeutic advancements derived from assessing the epitranscriptome.https://doi.org/10.1002/ibra.12183Alzheimer's diseaseepitranscriptomicsneurodegenerationParkinson's diseaseRNA modifications |
| spellingShingle | Muhammad Abu Talha Safdar Hashmi Hooriya Fatima Sadia Ahmad Amna Rehman Fiza Safdar The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies Ibrain Alzheimer's disease epitranscriptomics neurodegeneration Parkinson's disease RNA modifications |
| title | The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies |
| title_full | The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies |
| title_fullStr | The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies |
| title_full_unstemmed | The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies |
| title_short | The interplay between epitranscriptomic RNA modifications and neurodegenerative disorders: Mechanistic insights and potential therapeutic strategies |
| title_sort | interplay between epitranscriptomic rna modifications and neurodegenerative disorders mechanistic insights and potential therapeutic strategies |
| topic | Alzheimer's disease epitranscriptomics neurodegeneration Parkinson's disease RNA modifications |
| url | https://doi.org/10.1002/ibra.12183 |
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