Menin‐regulated Pbk controls high fat diet‐induced compensatory beta cell proliferation

Menin‐regulated Pbk controls high fat diet‐induced compensatory beta cell proliferation

Abstract Pancreatic beta cells undergo compensatory proliferation in the early phase of type 2 diabetes. While pathways such as FoxM1 are involved in regulating compensatory beta cell proliferation, given the lack of therapeutics effectively targeting beta cell proliferation, other targetable pathwa...

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Main Authors: Jian Ma, Bowen Xing, Yan Cao, Xin He, Kate E Bennett, Chao Tong, Chiying An, Taylor Hojnacki, Zijie Feng, Sunbin Deng, Sunbin Ling, Gengchen Xie, Yuan Wu, Yue Ren, Ming Yu, Bryson W Katona, Hongzhe Li, Ali Naji, Xianxin Hua
Format: Article
Language:English
Published: Springer Nature 2021-04-01
Series:EMBO Molecular Medicine
Subjects:
beta cell
compensatory proliferation
diabetes
menin
Pbk
Online Access:https://doi.org/10.15252/emmm.202013524
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https://doi.org/10.15252/emmm.202013524

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