Parkinsonism disrupts cortical function by dysregulating oscillatory, network and synaptic activity of parvalbumin positive interneurons

Parkinsonism disrupts cortical function by dysregulating oscillatory, network and synaptic activity of parvalbumin positive interneurons

Abstract Identifying novel and accessible therapeutic targets for Parkinson’s Disease (PD) remains a pressing goal. Growing evidence implicates cortical dysfunctions in PD-related symptoms, yet the mechanisms—especially those involving parvalbumin-positive interneurons (PV-INs), key regulators of br...

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Main Authors: Antea Minetti, Elena Montagni, Nicolò Meneghetti, Francesca Macchi, Éléa Coulomb, Alessandra Martello, Alexia Tiberi, Simona Capsoni, Alberto Mazzoni, Anna Letizia Allegra Mascaro, Cristina Spalletti
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01052-6
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