Miniaturized sample preparation strategies for the determination of N-nitrosamines in pharmaceutical products: A comprehensive review

Miniaturized sample preparation strategies for the determination of N-nitrosamines in pharmaceutical products: A comprehensive review

N-Nitrosamines (NAs) are classified as potent mutagenic impurities, raising substantial concerns due to their presence in various consumer products, including pharmaceuticals products. The detection of NAs in valsartan-containing medicines in 2018 led regulatory agencies to establish strict guidelin...

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Bibliographic Details
Main Authors:	Almir Custodio Batista Junior, Yuri Arrates Rocha, Andrea Rodrigues Chaves
Format:	Article
Language:	English
Published:	Elsevier 2025-12-01
Series:	Journal of Pharmaceutical and Biomedical Analysis Open
Subjects:	Sartan medicines Nitrosodiethylamine Nitrosodimethylamine Chromatography Mass Spectrometry
Online Access:	http://www.sciencedirect.com/science/article/pii/S2949771X25000325
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