The Role of Unsaturated Fatty Acid-Rich Dairy Products in Adipocyte Metabolism
This study investigated the fatty acid profile, permeability, and metabolic effects of a functional yogurt enriched with pomegranate oil, focusing on its impact on lipid metabolism and inflammatory responses. The yogurt’s fatty acid composition was primarily composed of long-chain polyunsaturated fa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/23/5502 |
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| author | Manuela Machado Eduardo M. Costa Sara Silva Ana Maria Gomes Manuela Pintado |
| author_facet | Manuela Machado Eduardo M. Costa Sara Silva Ana Maria Gomes Manuela Pintado |
| author_sort | Manuela Machado |
| collection | DOAJ |
| description | This study investigated the fatty acid profile, permeability, and metabolic effects of a functional yogurt enriched with pomegranate oil, focusing on its impact on lipid metabolism and inflammatory responses. The yogurt’s fatty acid composition was primarily composed of long-chain polyunsaturated fatty acids (54.37%), followed by saturated (29.34%) and monounsaturated fatty acids (16.36%). During in vitro digestion, a shift in fatty acid profile was observed, with a decrease in polyunsaturated and saturated fatty acids and a slight increase in monounsaturated fatty acids due to hydrolysis. This study further analyzed fatty acid permeability across Caco-2/HT29-MTX monolayers and 3T3-L1 cell uptake, revealing higher permeability for saturated fatty acids than unsaturated ones. In 3T3-L1 cells, permeated fatty acids induced higher lipolysis and increased adiponectin secretion without affecting leptin levels. Cytokine analysis indicated a decrease in pro-inflammatory markers, such as MCP-1, and a significant increase in anti-inflammatory cytokines like IL-10, suggesting potential benefits in reducing obesity-related inflammation. These results underscore the role of functional yogurts enriched with polyunsaturated fatty acids as promising agents for modulating lipid metabolism and inflammatory responses. |
| format | Article |
| id | doaj-art-d7028c98a8f44f56bff229ca74d0f2c6 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-d7028c98a8f44f56bff229ca74d0f2c62024-12-13T16:28:06ZengMDPI AGMolecules1420-30492024-11-012923550210.3390/molecules29235502The Role of Unsaturated Fatty Acid-Rich Dairy Products in Adipocyte MetabolismManuela Machado0Eduardo M. Costa1Sara Silva2Ana Maria Gomes3Manuela Pintado4Universidade Católica Portuguesa, CBQF Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, PortugalUniversidade Católica Portuguesa, CBQF Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, PortugalUniversidade Católica Portuguesa, CBQF Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, PortugalUniversidade Católica Portuguesa, CBQF Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, PortugalUniversidade Católica Portuguesa, CBQF Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, PortugalThis study investigated the fatty acid profile, permeability, and metabolic effects of a functional yogurt enriched with pomegranate oil, focusing on its impact on lipid metabolism and inflammatory responses. The yogurt’s fatty acid composition was primarily composed of long-chain polyunsaturated fatty acids (54.37%), followed by saturated (29.34%) and monounsaturated fatty acids (16.36%). During in vitro digestion, a shift in fatty acid profile was observed, with a decrease in polyunsaturated and saturated fatty acids and a slight increase in monounsaturated fatty acids due to hydrolysis. This study further analyzed fatty acid permeability across Caco-2/HT29-MTX monolayers and 3T3-L1 cell uptake, revealing higher permeability for saturated fatty acids than unsaturated ones. In 3T3-L1 cells, permeated fatty acids induced higher lipolysis and increased adiponectin secretion without affecting leptin levels. Cytokine analysis indicated a decrease in pro-inflammatory markers, such as MCP-1, and a significant increase in anti-inflammatory cytokines like IL-10, suggesting potential benefits in reducing obesity-related inflammation. These results underscore the role of functional yogurts enriched with polyunsaturated fatty acids as promising agents for modulating lipid metabolism and inflammatory responses.https://www.mdpi.com/1420-3049/29/23/5502fatty acid permeabilityadipocyte metabolisminflammatory cytokinesfunctional food |
| spellingShingle | Manuela Machado Eduardo M. Costa Sara Silva Ana Maria Gomes Manuela Pintado The Role of Unsaturated Fatty Acid-Rich Dairy Products in Adipocyte Metabolism Molecules fatty acid permeability adipocyte metabolism inflammatory cytokines functional food |
| title | The Role of Unsaturated Fatty Acid-Rich Dairy Products in Adipocyte Metabolism |
| title_full | The Role of Unsaturated Fatty Acid-Rich Dairy Products in Adipocyte Metabolism |
| title_fullStr | The Role of Unsaturated Fatty Acid-Rich Dairy Products in Adipocyte Metabolism |
| title_full_unstemmed | The Role of Unsaturated Fatty Acid-Rich Dairy Products in Adipocyte Metabolism |
| title_short | The Role of Unsaturated Fatty Acid-Rich Dairy Products in Adipocyte Metabolism |
| title_sort | role of unsaturated fatty acid rich dairy products in adipocyte metabolism |
| topic | fatty acid permeability adipocyte metabolism inflammatory cytokines functional food |
| url | https://www.mdpi.com/1420-3049/29/23/5502 |
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