Condition optimization for electroporation transfection in horse skeletal muscle satellite cells

Satellite cells are an important cellular model for studying muscle growth and development and mammalian locomotion-related molecular mechanisms. In this study, we investigated the effects of voltage, pulse duration, and DNA dosage on horse skeletal muscle satellite cells’ electroporation transfecti...

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Main Authors: Tseweendolmaa Ulaangerel, Minna Yi, Undarmaa Budsuren, Yingchao Shen, Hong Ren, Bold Demuul, Dongyi Bai, Dulguun Dorjgotov, Gantulga Davaakhuu, Tuyatsetseg Jambal, Manglai Dugarjav, Gerelchimeg Bou
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Animal Biotechnology
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Online Access:https://www.tandfonline.com/doi/10.1080/10495398.2023.2280664
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author Tseweendolmaa Ulaangerel
Minna Yi
Undarmaa Budsuren
Yingchao Shen
Hong Ren
Bold Demuul
Dongyi Bai
Dulguun Dorjgotov
Gantulga Davaakhuu
Tuyatsetseg Jambal
Manglai Dugarjav
Gerelchimeg Bou
author_facet Tseweendolmaa Ulaangerel
Minna Yi
Undarmaa Budsuren
Yingchao Shen
Hong Ren
Bold Demuul
Dongyi Bai
Dulguun Dorjgotov
Gantulga Davaakhuu
Tuyatsetseg Jambal
Manglai Dugarjav
Gerelchimeg Bou
author_sort Tseweendolmaa Ulaangerel
collection DOAJ
description Satellite cells are an important cellular model for studying muscle growth and development and mammalian locomotion-related molecular mechanisms. In this study, we investigated the effects of voltage, pulse duration, and DNA dosage on horse skeletal muscle satellite cells’ electroporation transfection efficiency using the eukaryotic expression plasmid Td Tomato-C1 (5.5 kb) encoding the red fluorescent protein gene mainly based on fluorescence-positive cell rate and cell survival rate. By comparison of different voltages, pulse durations, and DNA doses, horse skeletal muscle satellite cells have nearly 80% transfection efficiency under the condition of voltage 120 V, DNA dosage 7 µg/ml, and pulse duration 30 ms. This optimized electroporation condition would facilitate the application of horse skeletal muscle satellite cells in genetic studies of muscle function and related diseases.
format Article
id doaj-art-d6f8bef933444d1784cea60fcf819c6e
institution Kabale University
issn 1049-5398
1532-2378
language English
publishDate 2024-12-01
publisher Taylor & Francis Group
record_format Article
series Animal Biotechnology
spelling doaj-art-d6f8bef933444d1784cea60fcf819c6e2024-12-31T18:28:13ZengTaylor & Francis GroupAnimal Biotechnology1049-53981532-23782024-12-0135110.1080/10495398.2023.2280664Condition optimization for electroporation transfection in horse skeletal muscle satellite cellsTseweendolmaa Ulaangerel0Minna Yi1Undarmaa Budsuren2Yingchao Shen3Hong Ren4Bold Demuul5Dongyi Bai6Dulguun Dorjgotov7Gantulga Davaakhuu8Tuyatsetseg Jambal9Manglai Dugarjav10Gerelchimeg Bou11lnner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Chinalnner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Chinalnner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Chinalnner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Chinalnner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Chinalnner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Chinalnner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, College of Animal Science, Inner Mongolia Agricultural University, Hohhot, ChinaSchool of Industrial Technology, Mongolian University of Science and Technology, Ulaanbaatar, MongoliaInstitute of General and Experimental Biology, Mongolian Academy of Science, Ulaanbaatar, MongoliaSchool of Industrial Technology, Mongolian University of Science and Technology, Ulaanbaatar, Mongolialnner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, College of Animal Science, Inner Mongolia Agricultural University, Hohhot, Chinalnner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, College of Animal Science, Inner Mongolia Agricultural University, Hohhot, ChinaSatellite cells are an important cellular model for studying muscle growth and development and mammalian locomotion-related molecular mechanisms. In this study, we investigated the effects of voltage, pulse duration, and DNA dosage on horse skeletal muscle satellite cells’ electroporation transfection efficiency using the eukaryotic expression plasmid Td Tomato-C1 (5.5 kb) encoding the red fluorescent protein gene mainly based on fluorescence-positive cell rate and cell survival rate. By comparison of different voltages, pulse durations, and DNA doses, horse skeletal muscle satellite cells have nearly 80% transfection efficiency under the condition of voltage 120 V, DNA dosage 7 µg/ml, and pulse duration 30 ms. This optimized electroporation condition would facilitate the application of horse skeletal muscle satellite cells in genetic studies of muscle function and related diseases.https://www.tandfonline.com/doi/10.1080/10495398.2023.2280664Horsesatellite cellselectroporation transfectionparameter optimization
spellingShingle Tseweendolmaa Ulaangerel
Minna Yi
Undarmaa Budsuren
Yingchao Shen
Hong Ren
Bold Demuul
Dongyi Bai
Dulguun Dorjgotov
Gantulga Davaakhuu
Tuyatsetseg Jambal
Manglai Dugarjav
Gerelchimeg Bou
Condition optimization for electroporation transfection in horse skeletal muscle satellite cells
Animal Biotechnology
Horse
satellite cells
electroporation transfection
parameter optimization
title Condition optimization for electroporation transfection in horse skeletal muscle satellite cells
title_full Condition optimization for electroporation transfection in horse skeletal muscle satellite cells
title_fullStr Condition optimization for electroporation transfection in horse skeletal muscle satellite cells
title_full_unstemmed Condition optimization for electroporation transfection in horse skeletal muscle satellite cells
title_short Condition optimization for electroporation transfection in horse skeletal muscle satellite cells
title_sort condition optimization for electroporation transfection in horse skeletal muscle satellite cells
topic Horse
satellite cells
electroporation transfection
parameter optimization
url https://www.tandfonline.com/doi/10.1080/10495398.2023.2280664
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AT bolddemuul conditionoptimizationforelectroporationtransfectioninhorseskeletalmusclesatellitecells
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AT tuyatsetsegjambal conditionoptimizationforelectroporationtransfectioninhorseskeletalmusclesatellitecells
AT manglaidugarjav conditionoptimizationforelectroporationtransfectioninhorseskeletalmusclesatellitecells
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