CD28 is superior to 4-1BB costimulation in generating CAR-NK cells for tumor immunotherapy

CD28 is superior to 4-1BB costimulation in generating CAR-NK cells for tumor immunotherapy

Abstract Chimeric antigen receptor (CAR)-NK therapy holds great potential for tumor treatment, but current CAR designs are primarily optimized for T cells, raising concerns about their suitability for NK cells. This study compared two dominant CAR designs used in T cells—CD28-CD3ζ (28z) and 4-1BB-CD...

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Bibliographic Details
Main Authors: Pengchao Zhang, Xuejia Feng, Xiangyun Niu, Zhongming Liu, Minghui Li, Maoxuan Liu, Dehong Yan, Guizhong Zhang, Xiaochun Wan
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Experimental Hematology & Oncology
Subjects:
CAR-NK
Transcriptomics
CD28
4-1BB
MAP3K8
Online Access:https://doi.org/10.1186/s40164-025-00618-7
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