Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook
Newcastle disease (ND) is one of the most important avian diseases with considerable threat to the productivity of poultry all over the world. The disease is associated with severe respiratory, gastrointestinal, and neurological lesions in chicken leading to high mortality and several other producti...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2018/6097291 |
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| author | Muhammad Bashir Bello Khatijah Mohd Yusoff Aini Ideris Mohd Hair-Bejo Ben P. H. Peeters Abdurrahman Hassan Jibril Farouk Muhammad Tambuwal Abdul Rahman Omar |
| author_facet | Muhammad Bashir Bello Khatijah Mohd Yusoff Aini Ideris Mohd Hair-Bejo Ben P. H. Peeters Abdurrahman Hassan Jibril Farouk Muhammad Tambuwal Abdul Rahman Omar |
| author_sort | Muhammad Bashir Bello |
| collection | DOAJ |
| description | Newcastle disease (ND) is one of the most important avian diseases with considerable threat to the productivity of poultry all over the world. The disease is associated with severe respiratory, gastrointestinal, and neurological lesions in chicken leading to high mortality and several other production related losses. The aetiology of the disease is an avian paramyxovirus type-1 or Newcastle disease virus (NDV), whose isolates are serologically grouped into a single serotype but genetically classified into a total of 19 genotypes, owing to the continuous emergence and evolution of the virus. In Nigeria, molecular characterization of NDV is generally very scanty and majorly focuses on the amplification of the partial F gene for genotype assignment. However, with the introduction of the most objective NDV genotyping criteria which utilize complete fusion protein coding sequences in phylogenetic taxonomy, the enormous genetic diversity of the virus in Nigeria became very conspicuous. In this review, we examine the current ecological distribution of various NDV genotypes in Nigeria based on the available complete fusion protein nucleotide sequences (1662 bp) in the NCBI database. We then discuss the challenges of ND control as a result of the wide genetic distance between the currently circulating NDV isolates and the commonest vaccines used to combat the disease in the country. Finally, we suggest future directions in the war against the economically devastating ND in Nigeria. |
| format | Article |
| id | doaj-art-d6ecfc63f21d428ba8065ce18181b514 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-d6ecfc63f21d428ba8065ce18181b5142025-02-03T05:47:19ZengWileyAdvances in Virology1687-86391687-86472018-01-01201810.1155/2018/60972916097291Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future OutlookMuhammad Bashir Bello0Khatijah Mohd Yusoff1Aini Ideris2Mohd Hair-Bejo3Ben P. H. Peeters4Abdurrahman Hassan Jibril5Farouk Muhammad Tambuwal6Abdul Rahman Omar7Faculty of Veterinary Medicine, Usmanu Danfodiyo University, PMB 2346, Sokoto, NigeriaLaboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaLaboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaLaboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDivision of Virology, Central Veterinary Institute, Wageningen University, P.O. Box 65, NL8200 Lelystad, NetherlandsFaculty of Veterinary Medicine, Usmanu Danfodiyo University, PMB 2346, Sokoto, NigeriaFaculty of Veterinary Medicine, Usmanu Danfodiyo University, PMB 2346, Sokoto, NigeriaLaboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaNewcastle disease (ND) is one of the most important avian diseases with considerable threat to the productivity of poultry all over the world. The disease is associated with severe respiratory, gastrointestinal, and neurological lesions in chicken leading to high mortality and several other production related losses. The aetiology of the disease is an avian paramyxovirus type-1 or Newcastle disease virus (NDV), whose isolates are serologically grouped into a single serotype but genetically classified into a total of 19 genotypes, owing to the continuous emergence and evolution of the virus. In Nigeria, molecular characterization of NDV is generally very scanty and majorly focuses on the amplification of the partial F gene for genotype assignment. However, with the introduction of the most objective NDV genotyping criteria which utilize complete fusion protein coding sequences in phylogenetic taxonomy, the enormous genetic diversity of the virus in Nigeria became very conspicuous. In this review, we examine the current ecological distribution of various NDV genotypes in Nigeria based on the available complete fusion protein nucleotide sequences (1662 bp) in the NCBI database. We then discuss the challenges of ND control as a result of the wide genetic distance between the currently circulating NDV isolates and the commonest vaccines used to combat the disease in the country. Finally, we suggest future directions in the war against the economically devastating ND in Nigeria.http://dx.doi.org/10.1155/2018/6097291 |
| spellingShingle | Muhammad Bashir Bello Khatijah Mohd Yusoff Aini Ideris Mohd Hair-Bejo Ben P. H. Peeters Abdurrahman Hassan Jibril Farouk Muhammad Tambuwal Abdul Rahman Omar Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook Advances in Virology |
| title | Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook |
| title_full | Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook |
| title_fullStr | Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook |
| title_full_unstemmed | Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook |
| title_short | Genotype Diversity of Newcastle Disease Virus in Nigeria: Disease Control Challenges and Future Outlook |
| title_sort | genotype diversity of newcastle disease virus in nigeria disease control challenges and future outlook |
| url | http://dx.doi.org/10.1155/2018/6097291 |
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