Localized propranolol delivery from a copper-loaded hydrogel for enhancing infected burn wound healing via adrenergic β-receptor blockade

Localized propranolol delivery from a copper-loaded hydrogel for enhancing infected burn wound healing via adrenergic β-receptor blockade

Severe burn injuries immediately trigger a sustained systemic and local stress response. During this process, the sympathetic nervous system releases large amounts of catecholamines, which bind to β-adrenergic receptors (β-AR) on cell membranes, negatively affecting skin regeneration. Additionally,...

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Bibliographic Details
Main Authors: Wenzhe Sun, Hongwei Lu, Pengqin Zhang, Lian Zeng, Bing Ye, Yi Xu, Jianan Chen, Peiran Xue, Jialin Yu, Kaifang Chen, Bin Wu, Xiao Lv, Xiaodong Guo, Yanzhen Qu
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Materials Today Bio
Subjects:
Burn wound healing
Hydrogel
Angiogenesis
Propranolol
Sympathetic nerves
Infection
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424004782
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