Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patients
Abstract This study evaluated the effectiveness of intraovarian platelet-rich plasma (PRP) injection in improving ovarian response and embryo quality in IVF patients with poor embryo quality in previous controlled ovarian hyperstimulation (COH) cycles. 74 patients participated, with 30 in the contro...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-82630-1 |
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| author | Tzu-Ning Yu Ming-Jer Chen Tsung-Hsien Lee Yi-Chun Chen En-Hui Cheng Chun-Chia Huang Chung-I Chen Chun-I Lee Maw-Sheng Lee Pin-Yao Lin |
| author_facet | Tzu-Ning Yu Ming-Jer Chen Tsung-Hsien Lee Yi-Chun Chen En-Hui Cheng Chun-Chia Huang Chung-I Chen Chun-I Lee Maw-Sheng Lee Pin-Yao Lin |
| author_sort | Tzu-Ning Yu |
| collection | DOAJ |
| description | Abstract This study evaluated the effectiveness of intraovarian platelet-rich plasma (PRP) injection in improving ovarian response and embryo quality in IVF patients with poor embryo quality in previous controlled ovarian hyperstimulation (COH) cycles. 74 patients participated, with 30 in the control group and 44 in the PRP group. PRP was injected during the follicular phase for the PRP group. The control group completed two COH cycles, while the PRP group underwent COH cycles before and after the PRP injection. In the first COH cycle, there were no significant differences between groups. However, in the second COH cycle, the PRP group showed significant improvements: the number of fertilized oocytes increased (5.2 ± 3.6 vs. 3.3 ± 3.5, p = 0.011), total blastocysts (1.7 ± 1.5 vs. 0.5 ± 0.7, p < 0.0001) and good quality blastocysts (0.6 ± 0.8 vs. 0 ± 0.2, P < 0.0001). The total blastocyst rate (35 ± 31% vs. 13 ± 24%, p = 0.001) and good quality blastocyst rate (14 ± 22% vs. 1 ± 3%, p < 0.0001) were also higher in the PRP group. The most notable benefits occurred when COH was conducted one to two months post-PRP injection. |
| format | Article |
| id | doaj-art-d6cde18d1add480aa056311d96168b89 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Scientific Reports |
| spelling | doaj-art-d6cde18d1add480aa056311d96168b892025-01-12T12:19:59ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-024-82630-1Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patientsTzu-Ning Yu0Ming-Jer Chen1Tsung-Hsien Lee2Yi-Chun Chen3En-Hui Cheng4Chun-Chia Huang5Chung-I Chen6Chun-I Lee7Maw-Sheng Lee8Pin-Yao Lin9Division of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalDivision of Infertility, Lee Women’s HospitalAbstract This study evaluated the effectiveness of intraovarian platelet-rich plasma (PRP) injection in improving ovarian response and embryo quality in IVF patients with poor embryo quality in previous controlled ovarian hyperstimulation (COH) cycles. 74 patients participated, with 30 in the control group and 44 in the PRP group. PRP was injected during the follicular phase for the PRP group. The control group completed two COH cycles, while the PRP group underwent COH cycles before and after the PRP injection. In the first COH cycle, there were no significant differences between groups. However, in the second COH cycle, the PRP group showed significant improvements: the number of fertilized oocytes increased (5.2 ± 3.6 vs. 3.3 ± 3.5, p = 0.011), total blastocysts (1.7 ± 1.5 vs. 0.5 ± 0.7, p < 0.0001) and good quality blastocysts (0.6 ± 0.8 vs. 0 ± 0.2, P < 0.0001). The total blastocyst rate (35 ± 31% vs. 13 ± 24%, p = 0.001) and good quality blastocyst rate (14 ± 22% vs. 1 ± 3%, p < 0.0001) were also higher in the PRP group. The most notable benefits occurred when COH was conducted one to two months post-PRP injection.https://doi.org/10.1038/s41598-024-82630-1PRP (platelet-rich plasma)COH (controlled ovarian stimulation)IVF (in vitro fertilization)Embryo qualityBlastocyst formation |
| spellingShingle | Tzu-Ning Yu Ming-Jer Chen Tsung-Hsien Lee Yi-Chun Chen En-Hui Cheng Chun-Chia Huang Chung-I Chen Chun-I Lee Maw-Sheng Lee Pin-Yao Lin Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patients Scientific Reports PRP (platelet-rich plasma) COH (controlled ovarian stimulation) IVF (in vitro fertilization) Embryo quality Blastocyst formation |
| title | Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patients |
| title_full | Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patients |
| title_fullStr | Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patients |
| title_full_unstemmed | Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patients |
| title_short | Intraovarian platelet-rich plasma injection significantly improves blastocyst yield and quality in IVF patients |
| title_sort | intraovarian platelet rich plasma injection significantly improves blastocyst yield and quality in ivf patients |
| topic | PRP (platelet-rich plasma) COH (controlled ovarian stimulation) IVF (in vitro fertilization) Embryo quality Blastocyst formation |
| url | https://doi.org/10.1038/s41598-024-82630-1 |
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