Protein dysregulation during Leishmania infantum infection in anti-TNF immunosuppressed mice revealed through quantitative proteomics analysis of extracellular vesicles

Protein dysregulation during Leishmania infantum infection in anti-TNF immunosuppressed mice revealed through quantitative proteomics analysis of extracellular vesicles

IntroductionVisceral leishmaniasis (VL) occurs more frequently in immunosuppressed individuals, especially those undergoing immunosuppressive drug therapy for an autoimmune disease. In those receiving TNF antagonist therapy (anti-TNF), the course of VL is more severe and the response to traditional...

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Bibliographic Details
Main Authors: Lorena Bernardo, Ana Montero-Calle, Jose Carlos Solana, Marina Lozano-Rendal, Ana Torres, Carmen Sánchez, Rodrigo Barderas, Javier Moreno, Eugenia Carrillo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
extracellular vesicles
visceral leishmaniasis
immunosuppression
TNF antagonist
antimonials
quantitative proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1634080/full
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