Endothelial Foxo1 Phosphorylation Inhibition via Aptamer‐Liposome Alleviates OPN‐Induced Pathological Vascular Remodeling Following Spinal Cord Injury

Endothelial Foxo1 Phosphorylation Inhibition via Aptamer‐Liposome Alleviates OPN‐Induced Pathological Vascular Remodeling Following Spinal Cord Injury

Abstract Reconstruction of the neurovascular unit is essential for the repair of spinal cord injury (SCI). Nonetheless, detailed documentation of specific vascular changes following SCI and targeted interventions for vascular treatment remains limited. This study demonstrates that traumatic patholog...

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Main Authors: Jiaqi Xu, Chaoran Shi, Yinghe Ding, Tian Qin, Chengjun Li, Feifei Yuan, Yudong Liu, Yong Xie, Yiming Qin, Yong Cao, Tianding Wu, Chunyue Duan, Hongbin Lu, Jianzhong Hu, Liyuan Jiang
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
foxo1
osteopontin
spinal cord injury
targeted therapy
vascular remodeling
Online Access:https://doi.org/10.1002/advs.202406398
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