Advances in stress-tolerance elements for microbial cell factories
Microorganisms, particularly extremophiles, have evolved multiple adaptation mechanisms to address diverse stress conditions during survival in unique environments. Their responses to environmental coercion decide not only survival in severe conditions but are also an essential factor determining bi...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Synthetic and Systems Biotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405805X24000978 |
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| author | Zheyi Kuang Xiaofang Yan Yanfei Yuan Ruiqi Wang Haifan Zhu Youyang Wang Jianfeng Li Jianwen Ye Haitao Yue Xiaofeng Yang |
| author_facet | Zheyi Kuang Xiaofang Yan Yanfei Yuan Ruiqi Wang Haifan Zhu Youyang Wang Jianfeng Li Jianwen Ye Haitao Yue Xiaofeng Yang |
| author_sort | Zheyi Kuang |
| collection | DOAJ |
| description | Microorganisms, particularly extremophiles, have evolved multiple adaptation mechanisms to address diverse stress conditions during survival in unique environments. Their responses to environmental coercion decide not only survival in severe conditions but are also an essential factor determining bioproduction performance. The design of robust cell factories should take the balance of their growing and bioproduction into account. Thus, mining and redesigning stress-tolerance elements to optimize the performance of cell factories under various extreme conditions is necessary. Here, we reviewed several stress-tolerance elements, including acid-tolerant elements, saline-alkali-resistant elements, thermotolerant elements, antioxidant elements, and so on, providing potential materials for the construction of cell factories and the development of synthetic biology. Strategies for mining and redesigning stress-tolerance elements were also discussed. Moreover, several applications of stress-tolerance elements were provided, and perspectives and discussions for potential strategies for screening stress-tolerance elements were made. |
| format | Article |
| id | doaj-art-d694a128eb374db09b0fbbc6c95ff0c9 |
| institution | Kabale University |
| issn | 2405-805X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Synthetic and Systems Biotechnology |
| spelling | doaj-art-d694a128eb374db09b0fbbc6c95ff0c92024-12-15T06:16:05ZengKeAi Communications Co., Ltd.Synthetic and Systems Biotechnology2405-805X2024-12-0194793808Advances in stress-tolerance elements for microbial cell factoriesZheyi Kuang0Xiaofang Yan1Yanfei Yuan2Ruiqi Wang3Haifan Zhu4Youyang Wang5Jianfeng Li6Jianwen Ye7Haitao Yue8Xiaofeng Yang9School of Intelligence Science and Technology, Xinjiang University, Urumqi, 830017, ChinaSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, ChinaSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, ChinaSchool of Intelligence Science and Technology, Xinjiang University, Urumqi, 830017, ChinaSchool of Intelligence Science and Technology, Xinjiang University, Urumqi, 830017, ChinaSchool of Intelligence Science and Technology, Xinjiang University, Urumqi, 830017, ChinaSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, ChinaSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, ChinaSchool of Intelligence Science and Technology, Xinjiang University, Urumqi, 830017, China; Laboratory of Synthetic Biology, School of Life Science and Technology, Xinjiang University, Urumqi, 830017, China; 382 East Outer Loop Rd, School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, China.School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China; Corresponding author.Microorganisms, particularly extremophiles, have evolved multiple adaptation mechanisms to address diverse stress conditions during survival in unique environments. Their responses to environmental coercion decide not only survival in severe conditions but are also an essential factor determining bioproduction performance. The design of robust cell factories should take the balance of their growing and bioproduction into account. Thus, mining and redesigning stress-tolerance elements to optimize the performance of cell factories under various extreme conditions is necessary. Here, we reviewed several stress-tolerance elements, including acid-tolerant elements, saline-alkali-resistant elements, thermotolerant elements, antioxidant elements, and so on, providing potential materials for the construction of cell factories and the development of synthetic biology. Strategies for mining and redesigning stress-tolerance elements were also discussed. Moreover, several applications of stress-tolerance elements were provided, and perspectives and discussions for potential strategies for screening stress-tolerance elements were made.http://www.sciencedirect.com/science/article/pii/S2405805X24000978Stress-tolerance elementsSynthetic biologyCell factoryResistance mechanismApplication |
| spellingShingle | Zheyi Kuang Xiaofang Yan Yanfei Yuan Ruiqi Wang Haifan Zhu Youyang Wang Jianfeng Li Jianwen Ye Haitao Yue Xiaofeng Yang Advances in stress-tolerance elements for microbial cell factories Synthetic and Systems Biotechnology Stress-tolerance elements Synthetic biology Cell factory Resistance mechanism Application |
| title | Advances in stress-tolerance elements for microbial cell factories |
| title_full | Advances in stress-tolerance elements for microbial cell factories |
| title_fullStr | Advances in stress-tolerance elements for microbial cell factories |
| title_full_unstemmed | Advances in stress-tolerance elements for microbial cell factories |
| title_short | Advances in stress-tolerance elements for microbial cell factories |
| title_sort | advances in stress tolerance elements for microbial cell factories |
| topic | Stress-tolerance elements Synthetic biology Cell factory Resistance mechanism Application |
| url | http://www.sciencedirect.com/science/article/pii/S2405805X24000978 |
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