Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-Analysis
Background and Objectives: Toll-like receptor (TLR2) gene plays an important role in the pathogenesis of bacterial meningitis (such as meningococcal meningitis and pneumococcal meningitis). The association between TLR4 rs4986790 polymorphism and the susceptibility to bacterial meningitis has been ex...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Annals of Indian Academy of Neurology |
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| Online Access: | https://journals.lww.com/10.4103/aian.aian_443_24 |
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| author | Praveen Kumar Chandra Sekar Ramakrishnan Veerabathiran |
| author_facet | Praveen Kumar Chandra Sekar Ramakrishnan Veerabathiran |
| author_sort | Praveen Kumar Chandra Sekar |
| collection | DOAJ |
| description | Background and Objectives:
Toll-like receptor (TLR2) gene plays an important role in the pathogenesis of bacterial meningitis (such as meningococcal meningitis and pneumococcal meningitis). The association between TLR4 rs4986790 polymorphism and the susceptibility to bacterial meningitis has been extensively studied. However, the results of these studies remain inconsistent. Therefore, we performed a meta-analysis to evaluate the association between TLR4 rs4986790 polymorphism and the susceptibility to meningococcal meningitis and pneumococcal meningitis.
Methods:
Google Scholar, Embase, and PubMed databases were searched for case–control studies on TLR4 polymorphisms and the risks of meningococcal meningitis and pneumococcal meningitis, published up to May 31, 2024. To assess the strength of the association between TLR4 polymorphism and meningococcal meningitis and pneumococcal meningitis, the odds ratios (ORs) with 95% confidence intervals (CIs) were used. The meta-analysis of the associations between the TLR4 rs4986790 polymorphism and meningococcal meningitis and pneumococcal meningitis was carried out under different genetic models. Meta-analyses were conducted using Cochrane RoB 2 tool and Metagenyo to calculate the ORs and 95% CIs. Fourteen published studies with 3599 cases and 7438 controls were included.
Results:
Overall, there was a strong correlation between TLR4 polymorphisms and meningococcal meningitis observed across three genetic models using a random-effects model: GG + GA vs. AA (OR: 0.34, 95% CI: 0.14–0.79, P = 0.01, I² = 60%); GA vs. AA (OR: 0.34, 95% CI: 0.13–0.91, P = 0.03, I² = 65%); and GG vs. AA (OR: 0.34, 95% CI: 0.14–0.78, P = 0.01, I² = 59%). Conversely, a fixed-effects model also revealed a significant association in the G vs. A model (OR: 0.84, 95% CI: 0.73–0.96, P = 0.01, I² = 38%). In pneumococcal meningitis, a fixed-effects model analysis demonstrated a significant association in the GG vs. AA model (OR: 0.35, 95% CI: 0.14–0.87, P = 0.02, I² = 48%) respectively.
Conclusion:
This meta-analysis showed a strong correlation between TLR4 rs4986790 polymorphism and susceptibility to meningococcal meningitis and pneumococcal meningitis. Further studies with diverse populations are needed to validate and strengthen these findings. |
| format | Article |
| id | doaj-art-d67567e969da4d44813350e9fe4ce665 |
| institution | Kabale University |
| issn | 0972-2327 1998-3549 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj-art-d67567e969da4d44813350e9fe4ce6652025-01-06T14:22:14ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492024-12-0127662963710.4103/aian.aian_443_24Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-AnalysisPraveen Kumar Chandra SekarRamakrishnan VeerabathiranBackground and Objectives: Toll-like receptor (TLR2) gene plays an important role in the pathogenesis of bacterial meningitis (such as meningococcal meningitis and pneumococcal meningitis). The association between TLR4 rs4986790 polymorphism and the susceptibility to bacterial meningitis has been extensively studied. However, the results of these studies remain inconsistent. Therefore, we performed a meta-analysis to evaluate the association between TLR4 rs4986790 polymorphism and the susceptibility to meningococcal meningitis and pneumococcal meningitis. Methods: Google Scholar, Embase, and PubMed databases were searched for case–control studies on TLR4 polymorphisms and the risks of meningococcal meningitis and pneumococcal meningitis, published up to May 31, 2024. To assess the strength of the association between TLR4 polymorphism and meningococcal meningitis and pneumococcal meningitis, the odds ratios (ORs) with 95% confidence intervals (CIs) were used. The meta-analysis of the associations between the TLR4 rs4986790 polymorphism and meningococcal meningitis and pneumococcal meningitis was carried out under different genetic models. Meta-analyses were conducted using Cochrane RoB 2 tool and Metagenyo to calculate the ORs and 95% CIs. Fourteen published studies with 3599 cases and 7438 controls were included. Results: Overall, there was a strong correlation between TLR4 polymorphisms and meningococcal meningitis observed across three genetic models using a random-effects model: GG + GA vs. AA (OR: 0.34, 95% CI: 0.14–0.79, P = 0.01, I² = 60%); GA vs. AA (OR: 0.34, 95% CI: 0.13–0.91, P = 0.03, I² = 65%); and GG vs. AA (OR: 0.34, 95% CI: 0.14–0.78, P = 0.01, I² = 59%). Conversely, a fixed-effects model also revealed a significant association in the G vs. A model (OR: 0.84, 95% CI: 0.73–0.96, P = 0.01, I² = 38%). In pneumococcal meningitis, a fixed-effects model analysis demonstrated a significant association in the GG vs. AA model (OR: 0.35, 95% CI: 0.14–0.87, P = 0.02, I² = 48%) respectively. Conclusion: This meta-analysis showed a strong correlation between TLR4 rs4986790 polymorphism and susceptibility to meningococcal meningitis and pneumococcal meningitis. Further studies with diverse populations are needed to validate and strengthen these findings.https://journals.lww.com/10.4103/aian.aian_443_24toll-like receptormeningococcal diseasepneumococcal meningitisbacterial meningitis |
| spellingShingle | Praveen Kumar Chandra Sekar Ramakrishnan Veerabathiran Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-Analysis Annals of Indian Academy of Neurology toll-like receptor meningococcal disease pneumococcal meningitis bacterial meningitis |
| title | Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-Analysis |
| title_full | Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-Analysis |
| title_fullStr | Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-Analysis |
| title_short | Assessing the Impact of TLR4 rs4986790 Polymorphism on Bacterial Meningitis Risk: A Systematic Review and Meta-Analysis |
| title_sort | assessing the impact of tlr4 rs4986790 polymorphism on bacterial meningitis risk a systematic review and meta analysis |
| topic | toll-like receptor meningococcal disease pneumococcal meningitis bacterial meningitis |
| url | https://journals.lww.com/10.4103/aian.aian_443_24 |
| work_keys_str_mv | AT praveenkumarchandrasekar assessingtheimpactoftlr4rs4986790polymorphismonbacterialmeningitisriskasystematicreviewandmetaanalysis AT ramakrishnanveerabathiran assessingtheimpactoftlr4rs4986790polymorphismonbacterialmeningitisriskasystematicreviewandmetaanalysis |