Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities
Obesity has escalated into a critical global health crisis, tripling in prevalence since the mid-1970s. This increase mirrors the rise in metabolic-associated diseases such as type 2 diabetes (T2D) and its complications, certain cancers, and cardiovascular conditions. While substantial research effo...
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2024-11-01
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| author | Ebenezeri Erasto Ngowi Tuyan Lu Qing Liu Xianghong Xie Ning Wang Liping Luo Lijuan Deng Yinghua Zhou Zhihong Zhang Aijun Qiao |
| author_facet | Ebenezeri Erasto Ngowi Tuyan Lu Qing Liu Xianghong Xie Ning Wang Liping Luo Lijuan Deng Yinghua Zhou Zhihong Zhang Aijun Qiao |
| author_sort | Ebenezeri Erasto Ngowi |
| collection | DOAJ |
| description | Obesity has escalated into a critical global health crisis, tripling in prevalence since the mid-1970s. This increase mirrors the rise in metabolic-associated diseases such as type 2 diabetes (T2D) and its complications, certain cancers, and cardiovascular conditions. While substantial research efforts have enriched our understanding and led to the development of innovative management strategies for these diseases, the suboptimal response rates of existing therapies remain a major obstacle to effectively managing obesity and its associated conditions. Over the years, inter-organ communication (IOC) has emerged as a crucial factor in the development and progression of metabolic disorders. Exosomes, which are nano-sized vesicular couriers released by cells, play a significant role in this communication by transporting proteins, lipids, and nucleic acids across cellular landscapes. The available evidence indicates that exosomal RNAs present in biofluids such as blood, urine, milk, vitreous humor (VH), and cerebrospinal fluid (CSF) are altered in numerous diseases, suggesting their diagnostic and therapeutic potential. Long non-coding RNAs contained in exosomes (exo-lncRNAs) have attracted considerable interest, owing to their ability to interact with critical components involved in a multitude of metabolic pathways. Recent studies have found that alterations in exo-lncRNAs in biofluids correlate with several metabolic parameters in patients with metabolic-associated conditions; however, their exact roles remain largely unclear. This review highlights the diagnostic and therapeutic potential of exosomal lncRNAs in obesity and its associated conditions, emphasizing their role in IOC and disease progression, aiming to pave the way for further research in this promising domain. |
| format | Article |
| id | doaj-art-d66b922c839e4e86a881ab29f1e6dc28 |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-d66b922c839e4e86a881ab29f1e6dc282024-12-27T14:11:53ZengMDPI AGBiology2079-77372024-11-01131297610.3390/biology13120976Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related ComorbiditiesEbenezeri Erasto Ngowi0Tuyan Lu1Qing Liu2Xianghong Xie3Ning Wang4Liping Luo5Lijuan Deng6Yinghua Zhou7Zhihong Zhang8Aijun Qiao9Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, ChinaZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, ChinaZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, ChinaZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, ChinaZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, ChinaZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, ChinaZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, ChinaZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, ChinaZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, ChinaZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, ChinaObesity has escalated into a critical global health crisis, tripling in prevalence since the mid-1970s. This increase mirrors the rise in metabolic-associated diseases such as type 2 diabetes (T2D) and its complications, certain cancers, and cardiovascular conditions. While substantial research efforts have enriched our understanding and led to the development of innovative management strategies for these diseases, the suboptimal response rates of existing therapies remain a major obstacle to effectively managing obesity and its associated conditions. Over the years, inter-organ communication (IOC) has emerged as a crucial factor in the development and progression of metabolic disorders. Exosomes, which are nano-sized vesicular couriers released by cells, play a significant role in this communication by transporting proteins, lipids, and nucleic acids across cellular landscapes. The available evidence indicates that exosomal RNAs present in biofluids such as blood, urine, milk, vitreous humor (VH), and cerebrospinal fluid (CSF) are altered in numerous diseases, suggesting their diagnostic and therapeutic potential. Long non-coding RNAs contained in exosomes (exo-lncRNAs) have attracted considerable interest, owing to their ability to interact with critical components involved in a multitude of metabolic pathways. Recent studies have found that alterations in exo-lncRNAs in biofluids correlate with several metabolic parameters in patients with metabolic-associated conditions; however, their exact roles remain largely unclear. This review highlights the diagnostic and therapeutic potential of exosomal lncRNAs in obesity and its associated conditions, emphasizing their role in IOC and disease progression, aiming to pave the way for further research in this promising domain.https://www.mdpi.com/2079-7737/13/12/976biofluidsexosomeslong non-coding RNAsobesity and associated diseases |
| spellingShingle | Ebenezeri Erasto Ngowi Tuyan Lu Qing Liu Xianghong Xie Ning Wang Liping Luo Lijuan Deng Yinghua Zhou Zhihong Zhang Aijun Qiao Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities Biology biofluids exosomes long non-coding RNAs obesity and associated diseases |
| title | Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities |
| title_full | Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities |
| title_fullStr | Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities |
| title_full_unstemmed | Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities |
| title_short | Biofluid-Derived Exosomal LncRNAs: Their Potential in Obesity and Related Comorbidities |
| title_sort | biofluid derived exosomal lncrnas their potential in obesity and related comorbidities |
| topic | biofluids exosomes long non-coding RNAs obesity and associated diseases |
| url | https://www.mdpi.com/2079-7737/13/12/976 |
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