BISAP beyond pancreatitis: a new horizon in acute kidney injury prediction
Background:. Acute kidney injury (AKI) is a common complication in acute pancreatitis (AP), with a significant impact on mortality. The Bedside Index for Severity in Acute Pancreatitis (BISAP) score is well-established for assessing mortality risk in AP, but its utility in predicting AKI is less exp...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2024-12-01
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| Series: | Journal of Pancreatology |
| Online Access: | http://journals.lww.com/10.1097/JP9.0000000000000190 |
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| author | Mark Tawfik Omar Mourad Radu Grovu Chloe Lahoud Marina Makram Georges Khattar Yisroel Grabie Suzanne El-Sayegh |
| author_facet | Mark Tawfik Omar Mourad Radu Grovu Chloe Lahoud Marina Makram Georges Khattar Yisroel Grabie Suzanne El-Sayegh |
| author_sort | Mark Tawfik |
| collection | DOAJ |
| description | Background:. Acute kidney injury (AKI) is a common complication in acute pancreatitis (AP), with a significant impact on mortality. The Bedside Index for Severity in Acute Pancreatitis (BISAP) score is well-established for assessing mortality risk in AP, but its utility in predicting AKI is less explored.
Methods:. We conducted a retrospective chart review of 779 AP patients across 2 hospitals in New York, USA, from 2016 to 2022. Data on patient demographics, laboratory values, and vital signs were collected. BISAP scores were calculated. The primary outcome was AKI, defined by the KDIGO criteria. Multivariate logistic regression was done to assess the association between the BISAP score and AKI, adjusting for confounders. Secondary outcomes include the association of the BISAP score to hospital length of stay and mortality.
Results:. There was a significant association between the BISAP score and AKI, with an odds ratio of 2.36 (95% confidence interval [CI] = 1.42–4.41, P = .001), indicating a more than twofold increase in AKI risk for each point increase in BISAP score. The BISAP score was also significantly correlated with longer hospital stays and increased mortality risk.
Conclusion:. The BISAP score is a strong predictor of AKI in AP patients. This association and relation to hospital stay and mortality highlight the potential of the BISAP score as a comprehensive risk assessment tool in AP, especially for early identification of patients at high risk for AKI. This study paves the way for future research into risk-scoring systems for AKI in AP based on significant BISAP components. |
| format | Article |
| id | doaj-art-d65d2bf5959d4a66a84134d22e418c06 |
| institution | Kabale University |
| issn | 2096-5664 2577-3577 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Journal of Pancreatology |
| spelling | doaj-art-d65d2bf5959d4a66a84134d22e418c062024-12-24T09:46:38ZengWolters Kluwer Health/LWWJournal of Pancreatology2096-56642577-35772024-12-017425826610.1097/JP9.0000000000000190202412000-00006BISAP beyond pancreatitis: a new horizon in acute kidney injury predictionMark Tawfik0Omar Mourad1Radu Grovu2Chloe Lahoud3Marina Makram4Georges Khattar5Yisroel Grabie6Suzanne El-Sayegh7a Department of Internal Medicine, Staten Island University Hospital – Northwell Health, NY, USAa Department of Internal Medicine, Staten Island University Hospital – Northwell Health, NY, USAa Department of Internal Medicine, Staten Island University Hospital – Northwell Health, NY, USAa Department of Internal Medicine, Staten Island University Hospital – Northwell Health, NY, USAb Touro College of Osteopathic Medicine, Harlem, NY, USAa Department of Internal Medicine, Staten Island University Hospital – Northwell Health, NY, USAa Department of Internal Medicine, Staten Island University Hospital – Northwell Health, NY, USAc Department of Nephrology, Staten Island University Hospital – Northwell Health, NY, USABackground:. Acute kidney injury (AKI) is a common complication in acute pancreatitis (AP), with a significant impact on mortality. The Bedside Index for Severity in Acute Pancreatitis (BISAP) score is well-established for assessing mortality risk in AP, but its utility in predicting AKI is less explored. Methods:. We conducted a retrospective chart review of 779 AP patients across 2 hospitals in New York, USA, from 2016 to 2022. Data on patient demographics, laboratory values, and vital signs were collected. BISAP scores were calculated. The primary outcome was AKI, defined by the KDIGO criteria. Multivariate logistic regression was done to assess the association between the BISAP score and AKI, adjusting for confounders. Secondary outcomes include the association of the BISAP score to hospital length of stay and mortality. Results:. There was a significant association between the BISAP score and AKI, with an odds ratio of 2.36 (95% confidence interval [CI] = 1.42–4.41, P = .001), indicating a more than twofold increase in AKI risk for each point increase in BISAP score. The BISAP score was also significantly correlated with longer hospital stays and increased mortality risk. Conclusion:. The BISAP score is a strong predictor of AKI in AP patients. This association and relation to hospital stay and mortality highlight the potential of the BISAP score as a comprehensive risk assessment tool in AP, especially for early identification of patients at high risk for AKI. This study paves the way for future research into risk-scoring systems for AKI in AP based on significant BISAP components.http://journals.lww.com/10.1097/JP9.0000000000000190 |
| spellingShingle | Mark Tawfik Omar Mourad Radu Grovu Chloe Lahoud Marina Makram Georges Khattar Yisroel Grabie Suzanne El-Sayegh BISAP beyond pancreatitis: a new horizon in acute kidney injury prediction Journal of Pancreatology |
| title | BISAP beyond pancreatitis: a new horizon in acute kidney injury prediction |
| title_full | BISAP beyond pancreatitis: a new horizon in acute kidney injury prediction |
| title_fullStr | BISAP beyond pancreatitis: a new horizon in acute kidney injury prediction |
| title_full_unstemmed | BISAP beyond pancreatitis: a new horizon in acute kidney injury prediction |
| title_short | BISAP beyond pancreatitis: a new horizon in acute kidney injury prediction |
| title_sort | bisap beyond pancreatitis a new horizon in acute kidney injury prediction |
| url | http://journals.lww.com/10.1097/JP9.0000000000000190 |
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