Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study
Objectives This study aimed to evaluate the clinical value of the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) for assessing disease activity in patients with SLE.Methods Clinical data were collected from patients with SLE who were admitted at the Second Affiliated Hospital of Sooch...
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BMJ Publishing Group
2024-05-01
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| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/11/1/e001196.full |
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| author | Leixi Xue Zhichun Liu Lin Zhang Jinlu Ma Mengxue Yan |
| author_facet | Leixi Xue Zhichun Liu Lin Zhang Jinlu Ma Mengxue Yan |
| author_sort | Leixi Xue |
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| description | Objectives This study aimed to evaluate the clinical value of the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) for assessing disease activity in patients with SLE.Methods Clinical data were collected from patients with SLE who were admitted at the Second Affiliated Hospital of Soochow University from January 2009 to December 2022. The glucocorticoid dose grading was used as the gold standard for disease activity assessment in SLE. The SLE-DAS value was calculated, and the SLE disease activity status was graded based on the SLE-DAS value. Another scoring criterion, the SLE Disease Activity Index 2000 (SLEDAI 2000), served as a control. Spearman correlation analysis was used to calculate the correlation between the scoring criteria and other variables.Results The analysis included 396 patients with SLE. A strong correlation was found between SLE-DAS and SLEDAI 2000 (ρ=0.709, 95% CI 0.648 to 0.766, p<0.001), with median SLE-DAS and SLEDAI 2000 scores of 15.32 (7.90 to 24.45) and 13 (8 to 19), respectively. Compared with the SLEDAI 2000 value, the SLE-DAS value correlated better with glucocorticoid dose grading (ρ=0.434 vs 0.518), gammaglobulin use (ρ=0.170 vs 0.318) and immunosuppressant use (ρ=0.122 vs 0.221). A moderate correlation based on disease activity grading was found between SLE-DAS and glucocorticoid dose grading (ρ=0.441), whereas a mild correlation was observed between SLEDAI 2000 and glucocorticoid dose grading (ρ=0.325). Additionally, SLE-DAS revealed a positive correlation with severe thrombocytopenia, cardiac involvement and pulmonary involvement but not SLEDAI 2000.Conclusion Compared with SLEDAI 2000, SLE-DAS may provide a more accurate disease activity assessment in patients with SLE, especially those with severe thrombocytopenia and cardiopulmonary involvement. |
| format | Article |
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| institution | Kabale University |
| issn | 2053-8790 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | BMJ Publishing Group |
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| series | Lupus Science and Medicine |
| spelling | doaj-art-d65863f593af4159b94858891a76e3682024-11-10T06:45:07ZengBMJ Publishing GroupLupus Science and Medicine2053-87902024-05-0111110.1136/lupus-2024-001196Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective studyLeixi Xue0Zhichun Liu1Lin Zhang2Jinlu Ma3Mengxue Yan4Department of Rheumatology and Immunology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Rheumatology and Immunology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China3Monash University, AustraliaDepartment of Rheumatology and Immunology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Anesthesiology, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaObjectives This study aimed to evaluate the clinical value of the Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) for assessing disease activity in patients with SLE.Methods Clinical data were collected from patients with SLE who were admitted at the Second Affiliated Hospital of Soochow University from January 2009 to December 2022. The glucocorticoid dose grading was used as the gold standard for disease activity assessment in SLE. The SLE-DAS value was calculated, and the SLE disease activity status was graded based on the SLE-DAS value. Another scoring criterion, the SLE Disease Activity Index 2000 (SLEDAI 2000), served as a control. Spearman correlation analysis was used to calculate the correlation between the scoring criteria and other variables.Results The analysis included 396 patients with SLE. A strong correlation was found between SLE-DAS and SLEDAI 2000 (ρ=0.709, 95% CI 0.648 to 0.766, p<0.001), with median SLE-DAS and SLEDAI 2000 scores of 15.32 (7.90 to 24.45) and 13 (8 to 19), respectively. Compared with the SLEDAI 2000 value, the SLE-DAS value correlated better with glucocorticoid dose grading (ρ=0.434 vs 0.518), gammaglobulin use (ρ=0.170 vs 0.318) and immunosuppressant use (ρ=0.122 vs 0.221). A moderate correlation based on disease activity grading was found between SLE-DAS and glucocorticoid dose grading (ρ=0.441), whereas a mild correlation was observed between SLEDAI 2000 and glucocorticoid dose grading (ρ=0.325). Additionally, SLE-DAS revealed a positive correlation with severe thrombocytopenia, cardiac involvement and pulmonary involvement but not SLEDAI 2000.Conclusion Compared with SLEDAI 2000, SLE-DAS may provide a more accurate disease activity assessment in patients with SLE, especially those with severe thrombocytopenia and cardiopulmonary involvement.https://lupus.bmj.com/content/11/1/e001196.full |
| spellingShingle | Leixi Xue Zhichun Liu Lin Zhang Jinlu Ma Mengxue Yan Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study Lupus Science and Medicine |
| title | Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study |
| title_full | Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study |
| title_fullStr | Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study |
| title_full_unstemmed | Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study |
| title_short | Value of SLE-DAS in assessing disease activity in patients with systemic lupus erythematosus: a single-centre retrospective study |
| title_sort | value of sle das in assessing disease activity in patients with systemic lupus erythematosus a single centre retrospective study |
| url | https://lupus.bmj.com/content/11/1/e001196.full |
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