Identification of the Cytotoxic Transglutaminase from <i>Mycobacterium</i> spp. That Is Involved in RIPK1 Activation
Although the global incidence of tuberculosis has declined in recent years, tuberculosis remains a major global public health challenge. The <i>Mycobacterium tuberculosis</i> complex (MTBC) including <i>M. tuberculosis</i>, <i>M. bovis</i>, <i>M. microti<...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/10/2251 |
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| Summary: | Although the global incidence of tuberculosis has declined in recent years, tuberculosis remains a major global public health challenge. The <i>Mycobacterium tuberculosis</i> complex (MTBC) including <i>M. tuberculosis</i>, <i>M. bovis</i>, <i>M. microti</i>, etc., is the deadliest <i>Mycobacterium</i> spp. that needs more attention. Research on <i>M. microti</i> is significant as it is a zoonotic pathogen that can spread between animals and humans. By exploring the function of a transglutaminase in <i>M. microti</i> (MmTG), which is widely distributed in <i>Mycobacterium</i> and other species, a potential cytotoxic effector has been characterized. MmTG inhibits cell proliferation by inducing the phosphorylation of RIPK1 (receptor-interacting serine/threonine-protein kinase 1) and the Cys159 of MmTG is the highly conserved residue related to its cytotoxicity. Understanding MmTG and its homologs can provide more insights into the pathogenic mechanisms of mycobacteria and contribute to the development of more effective therapeutic strategies against mycobacterial infections. |
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| ISSN: | 1420-3049 |