The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational study
Abstract Purpose Previous studies have suggested a link between serum progesterone levels on the day of the HCG trigger in IVF cycles and oocyte and embryo quality. This study aims to explore this relationship more thoroughly. Methods This study included 496 infertility patients at Moloud Infertilit...
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BMC
2024-12-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-024-03535-9 |
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| author | Elham Hokmabadi Elnaz Salahi Marzieh Ghasemi |
| author_facet | Elham Hokmabadi Elnaz Salahi Marzieh Ghasemi |
| author_sort | Elham Hokmabadi |
| collection | DOAJ |
| description | Abstract Purpose Previous studies have suggested a link between serum progesterone levels on the day of the HCG trigger in IVF cycles and oocyte and embryo quality. This study aims to explore this relationship more thoroughly. Methods This study included 496 infertility patients at Moloud Infertility Treatment Center, Zahedan, Iran. Statistical methods were used to assess factors such as oocyte maturation and embryo quality, fertilization rate, BMI, and gonadotropin dosage. Results While an initial progesterone cutoff of 1.2 ng/ml was used to perform fundamental analysis, a more accurate cutoff of 1.54 ng/ml was identified, beyond which the average number of M1 oocytes significantly declined. A strong relationship was found between higher progesterone levels and a greater number of retrieved oocytes (p = 0.004), with M1 oocytes showing a similar relation. Also, BMI was significantly related to the quality of eight-cell grade B embryos (p = 0.006). However, no significant correlations were found between progesterone levels and other factors, including patient age (p = 0.327), fertilization rate (p = 0.603), or embryo quality at other stages. Conclusions The findings demonstrate that elevated progesterone level, particularly beyond the identified cutoff of 1.54 ng/ml, is a valuable clinical indicator of suboptimal IVF outcomes due to its negative impact on oocyte maturation. |
| format | Article |
| id | doaj-art-d63b7514650744ab95c497736c4a68c3 |
| institution | Kabale University |
| issn | 1472-6874 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | BMC Women's Health |
| spelling | doaj-art-d63b7514650744ab95c497736c4a68c32025-01-05T12:44:50ZengBMCBMC Women's Health1472-68742024-12-0124111110.1186/s12905-024-03535-9The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational studyElham Hokmabadi0Elnaz Salahi1Marzieh Ghasemi2Department of Obstetrics and Gynecology, Faculty of Medicine, Zahedan University of Medical SciencesDepartment of Obstetrics and Gynecology, Faculty of Medicine, Zahedan University of Medical SciencesDepartment of Obstetrics and Gynecology, Faculty of Medicine, Zahedan University of Medical SciencesAbstract Purpose Previous studies have suggested a link between serum progesterone levels on the day of the HCG trigger in IVF cycles and oocyte and embryo quality. This study aims to explore this relationship more thoroughly. Methods This study included 496 infertility patients at Moloud Infertility Treatment Center, Zahedan, Iran. Statistical methods were used to assess factors such as oocyte maturation and embryo quality, fertilization rate, BMI, and gonadotropin dosage. Results While an initial progesterone cutoff of 1.2 ng/ml was used to perform fundamental analysis, a more accurate cutoff of 1.54 ng/ml was identified, beyond which the average number of M1 oocytes significantly declined. A strong relationship was found between higher progesterone levels and a greater number of retrieved oocytes (p = 0.004), with M1 oocytes showing a similar relation. Also, BMI was significantly related to the quality of eight-cell grade B embryos (p = 0.006). However, no significant correlations were found between progesterone levels and other factors, including patient age (p = 0.327), fertilization rate (p = 0.603), or embryo quality at other stages. Conclusions The findings demonstrate that elevated progesterone level, particularly beyond the identified cutoff of 1.54 ng/ml, is a valuable clinical indicator of suboptimal IVF outcomes due to its negative impact on oocyte maturation.https://doi.org/10.1186/s12905-024-03535-9ProgesteroneHCG triggerIVFOocyte maturationEmbryo qualityInfertility |
| spellingShingle | Elham Hokmabadi Elnaz Salahi Marzieh Ghasemi The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational study BMC Women's Health Progesterone HCG trigger IVF Oocyte maturation Embryo quality Infertility |
| title | The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational study |
| title_full | The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational study |
| title_fullStr | The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational study |
| title_full_unstemmed | The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational study |
| title_short | The relationship between serum progesterone level on the day of HCG trigger in IVF/ICSI cycles and oocyte maturation and embryo quality: a retrospective observational study |
| title_sort | relationship between serum progesterone level on the day of hcg trigger in ivf icsi cycles and oocyte maturation and embryo quality a retrospective observational study |
| topic | Progesterone HCG trigger IVF Oocyte maturation Embryo quality Infertility |
| url | https://doi.org/10.1186/s12905-024-03535-9 |
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