Immunosenescence and its related comorbidities in older people living with HIV
Abstract. With the aging of the global population, older people living with HIV (OPLWH) have emerged as a focal point in HIV/AIDS research. Although antiretroviral therapy has demonstrated positive effects in OPLWH, concerns persist regarding overall poor immune reconstitution and elevated rates of...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health - Lippincott Williams Wilkins
2025-01-01
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| Series: | Infectious Diseases & Immunity |
| Online Access: | http://journals.lww.com/10.1097/ID9.0000000000000134 |
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| author | Xiao-Yan He Xiu-Wen Wang Shuang Li Na Li Wei Li Yan Hu Na Guo Yong-Tang Zheng Hong-Yi Zheng Bin Su Haijuan Wang |
| author_facet | Xiao-Yan He Xiu-Wen Wang Shuang Li Na Li Wei Li Yan Hu Na Guo Yong-Tang Zheng Hong-Yi Zheng Bin Su Haijuan Wang |
| author_sort | Xiao-Yan He |
| collection | DOAJ |
| description | Abstract. With the aging of the global population, older people living with HIV (OPLWH) have emerged as a focal point in HIV/AIDS research. Although antiretroviral therapy has demonstrated positive effects in OPLWH, concerns persist regarding overall poor immune reconstitution and elevated rates of age-related comorbidities, such as cardiovascular disease, bone disease, and cognitive impairment. This review aims to elucidate the mechanisms underlying immunosenescence and the interaction of immunosenescence with HIV infection, further exploring its role in the pathogenesis of HIV infection during aging. Aging-induced involution of the immune system, along with chronic inflammation and infection, can induce immunosenescence, leading to immune dysfunction that impairs the effective control of HIV infection. In addition, HIV infection induces immunosenescence through persistent inflammation and immune activation, even under treatment. The combined effects of aging and HIV infection accelerate the progression of immunosenescence in OPLWH, increasing their susceptibility to multiple age-related diseases. The unfavorable prognosis observed among OPLWH is largely attributed to increased levels of immunosenescence. A comprehensive understanding of the relationship between immunosenescence and HIV infection is crucial for developing targeted therapeutic strategies for this vulnerable population. |
| format | Article |
| id | doaj-art-d634bfbae1a24c73af73129837786117 |
| institution | Kabale University |
| issn | 2096-9511 2693-8839 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Health - Lippincott Williams Wilkins |
| record_format | Article |
| series | Infectious Diseases & Immunity |
| spelling | doaj-art-d634bfbae1a24c73af731298377861172025-01-14T07:30:25ZengWolters Kluwer Health - Lippincott Williams WilkinsInfectious Diseases & Immunity2096-95112693-88392025-01-0151445510.1097/ID9.0000000000000134202501000-00005Immunosenescence and its related comorbidities in older people living with HIVXiao-Yan He0Xiu-Wen Wang1Shuang Li2Na Li3Wei Li4Yan Hu5Na Guo6Yong-Tang Zheng7Hong-Yi Zheng8Bin Su9Haijuan Wang1 Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China3 Beijing Key Laboratory for HIV/AIDS Research, Sino-French Joint Laboratory for HIV/AIDS Research, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China3 Beijing Key Laboratory for HIV/AIDS Research, Sino-French Joint Laboratory for HIV/AIDS Research, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China4 School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China1 Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China1 Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China3 Beijing Key Laboratory for HIV/AIDS Research, Sino-French Joint Laboratory for HIV/AIDS Research, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China1 Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China1 Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China3 Beijing Key Laboratory for HIV/AIDS Research, Sino-French Joint Laboratory for HIV/AIDS Research, Beijing Youan Hospital, Capital Medical University, Beijing 100069, ChinaAbstract. With the aging of the global population, older people living with HIV (OPLWH) have emerged as a focal point in HIV/AIDS research. Although antiretroviral therapy has demonstrated positive effects in OPLWH, concerns persist regarding overall poor immune reconstitution and elevated rates of age-related comorbidities, such as cardiovascular disease, bone disease, and cognitive impairment. This review aims to elucidate the mechanisms underlying immunosenescence and the interaction of immunosenescence with HIV infection, further exploring its role in the pathogenesis of HIV infection during aging. Aging-induced involution of the immune system, along with chronic inflammation and infection, can induce immunosenescence, leading to immune dysfunction that impairs the effective control of HIV infection. In addition, HIV infection induces immunosenescence through persistent inflammation and immune activation, even under treatment. The combined effects of aging and HIV infection accelerate the progression of immunosenescence in OPLWH, increasing their susceptibility to multiple age-related diseases. The unfavorable prognosis observed among OPLWH is largely attributed to increased levels of immunosenescence. A comprehensive understanding of the relationship between immunosenescence and HIV infection is crucial for developing targeted therapeutic strategies for this vulnerable population.http://journals.lww.com/10.1097/ID9.0000000000000134 |
| spellingShingle | Xiao-Yan He Xiu-Wen Wang Shuang Li Na Li Wei Li Yan Hu Na Guo Yong-Tang Zheng Hong-Yi Zheng Bin Su Haijuan Wang Immunosenescence and its related comorbidities in older people living with HIV Infectious Diseases & Immunity |
| title | Immunosenescence and its related comorbidities in older people living with HIV |
| title_full | Immunosenescence and its related comorbidities in older people living with HIV |
| title_fullStr | Immunosenescence and its related comorbidities in older people living with HIV |
| title_full_unstemmed | Immunosenescence and its related comorbidities in older people living with HIV |
| title_short | Immunosenescence and its related comorbidities in older people living with HIV |
| title_sort | immunosenescence and its related comorbidities in older people living with hiv |
| url | http://journals.lww.com/10.1097/ID9.0000000000000134 |
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