Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer.
This study aimed to identify radiotherapy dosimetric parameters related to local failure (LF)-free survival (LFFS) in patients with lung and liver oligometastases from colorectal cancer treated with stereotactic body radiotherapy (SBRT). We analyzed 75 oligometastatic lesions in 55 patients treated...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0313438 |
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| author | Su Jin Kang Jongmoo Park Gyu-Seog Choi Jong Gwang Kim Jun Seok Park Hye Jin Kim Jin Ho Baek Byung Woog Kang An Na Seo Shin-Hyung Park Bong Kyung Bae Min Kyu Kang Soo Yeun Park |
| author_facet | Su Jin Kang Jongmoo Park Gyu-Seog Choi Jong Gwang Kim Jun Seok Park Hye Jin Kim Jin Ho Baek Byung Woog Kang An Na Seo Shin-Hyung Park Bong Kyung Bae Min Kyu Kang Soo Yeun Park |
| author_sort | Su Jin Kang |
| collection | DOAJ |
| description | This study aimed to identify radiotherapy dosimetric parameters related to local failure (LF)-free survival (LFFS) in patients with lung and liver oligometastases from colorectal cancer treated with stereotactic body radiotherapy (SBRT). We analyzed 75 oligometastatic lesions in 55 patients treated with SBRT between January 2014 and December 2021. There was no constraint or intentional increase in maximum dose. LF was defined as the progression of the treated lesion until the last follow-up or death. The dose distributions were recalculated using Monte Carlo-based algorithms. The significance of the planning target volume (PTV) biologically effective dose (BED) 10s (D2, D95, D98, Dmean) in LFFS was evaluated using Cox regression, considering sex, age, primary cancer, tumor site, oligometastatic status, multiplicity, and either tumor size or one of the volume parameters. LF occurred in 23.4% of the lesions. Lesions showing LF received significantly lower PTV D2 (146 ± 21 vs. 164 ± 23, p = 0.006). Multivariate analysis revealed that PTV D2 (< 159 Gy10 vs. ≥ 159 Gy10) was the sole dosimetric parameter associated with LFFS. Tumors equal to or larger than the median size/volume yet receiving < 159 Gy10 of PTV D2 showed the lowest LFFS following stratification by median PTV D2 combined with tumor size or volume parameters. The maximum dose (PTV D2) was significantly associated with LFFS after SBRT for lung and liver oligometastases from colorectal cancer. Increasing the maximum dose may be beneficial for managing larger tumors. |
| format | Article |
| id | doaj-art-d61f85ed952341f09d7356ba9858162f |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-d61f85ed952341f09d7356ba9858162f2025-01-08T05:31:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031343810.1371/journal.pone.0313438Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer.Su Jin KangJongmoo ParkGyu-Seog ChoiJong Gwang KimJun Seok ParkHye Jin KimJin Ho BaekByung Woog KangAn Na SeoShin-Hyung ParkBong Kyung BaeMin Kyu KangSoo Yeun ParkThis study aimed to identify radiotherapy dosimetric parameters related to local failure (LF)-free survival (LFFS) in patients with lung and liver oligometastases from colorectal cancer treated with stereotactic body radiotherapy (SBRT). We analyzed 75 oligometastatic lesions in 55 patients treated with SBRT between January 2014 and December 2021. There was no constraint or intentional increase in maximum dose. LF was defined as the progression of the treated lesion until the last follow-up or death. The dose distributions were recalculated using Monte Carlo-based algorithms. The significance of the planning target volume (PTV) biologically effective dose (BED) 10s (D2, D95, D98, Dmean) in LFFS was evaluated using Cox regression, considering sex, age, primary cancer, tumor site, oligometastatic status, multiplicity, and either tumor size or one of the volume parameters. LF occurred in 23.4% of the lesions. Lesions showing LF received significantly lower PTV D2 (146 ± 21 vs. 164 ± 23, p = 0.006). Multivariate analysis revealed that PTV D2 (< 159 Gy10 vs. ≥ 159 Gy10) was the sole dosimetric parameter associated with LFFS. Tumors equal to or larger than the median size/volume yet receiving < 159 Gy10 of PTV D2 showed the lowest LFFS following stratification by median PTV D2 combined with tumor size or volume parameters. The maximum dose (PTV D2) was significantly associated with LFFS after SBRT for lung and liver oligometastases from colorectal cancer. Increasing the maximum dose may be beneficial for managing larger tumors.https://doi.org/10.1371/journal.pone.0313438 |
| spellingShingle | Su Jin Kang Jongmoo Park Gyu-Seog Choi Jong Gwang Kim Jun Seok Park Hye Jin Kim Jin Ho Baek Byung Woog Kang An Na Seo Shin-Hyung Park Bong Kyung Bae Min Kyu Kang Soo Yeun Park Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer. PLoS ONE |
| title | Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer. |
| title_full | Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer. |
| title_fullStr | Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer. |
| title_full_unstemmed | Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer. |
| title_short | Effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer. |
| title_sort | effects of maximum dose on local control after stereotactic body radiotherapy for oligometastatic tumors of colorectal cancer |
| url | https://doi.org/10.1371/journal.pone.0313438 |
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