Development of an Ion‐Sensitive Field‐Effect Transistor Device for High‐Performance Diagnostic and Clinical Biomedical Applications
ABSTRACT Ion‐sensitive field‐effect transistors (ISFETs) represent a promising technology for the precise detection of ions, particularly within diagnostic and clinical biomedical contexts. This paper details the design and implementation of an ISFET‐based device tailored specifically for efficient...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-04-01
|
| Series: | Engineering Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/eng2.70126 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | ABSTRACT Ion‐sensitive field‐effect transistors (ISFETs) represent a promising technology for the precise detection of ions, particularly within diagnostic and clinical biomedical contexts. This paper details the design and implementation of an ISFET‐based device tailored specifically for efficient and reliable ion detection in biomedical settings. By meticulously selecting materials, configuring sensors, and integrating specialized readout circuitry, the device exhibits exceptional sensitivity and specificity in detecting target ions pertinent to various biomedical assays. The design process involves thorough optimization for sensitivity, durability, and compatibility with biological samples. A comprehensive review of ISFET gate materials is provided, alongside an overview of typical gate structures and signal readout methods for ISFET sensing systems. Additionally, diverse biosensing applications including ions, deoxyribonucleic acid, proteins, and microbes are explored. Rigorous calibration and testing procedures ensure precise and reproducible measurements. The resulting device holds substantial promise for applications such as pH monitoring, ion analysis, and biomarker detection in clinical diagnostics, offering a versatile platform for advancing biomedical research and healthcare practices. In the experimental investigation of pH sensor performance, five distinct measurements of current sensitivity were recorded. The obtained values were 0.025, 0.028, 0.027, 0.026, and 0.030 mA/pH, respectively. These measurements serve as crucial indicators of the sensor's responsiveness to changes in pH levels, providing insights into its effectiveness in detecting subtle variations in acidity or alkalinity. Such precise data are essential for evaluating and optimizing the sensor's design and functionality for various practical applications in analytical chemistry, environmental monitoring, and biomedical diagnostics. |
|---|---|
| ISSN: | 2577-8196 |