Concentration-dependent effects of immunomodulatory cocktails on the generation of leukemia-derived dendritic cells, DCleu mediated T-cell activation and on-target/off-tumor toxicity

Concentration-dependent effects of immunomodulatory cocktails on the generation of leukemia-derived dendritic cells, DCleu mediated T-cell activation and on-target/off-tumor toxicity

Acute myeloid leukemia (AML) remains a devastating diagnosis in clear need of therapeutic advances. Both targeted dendritic cells (DC) and particularly leukemia-derived dendritic cells (DCleu) can exert potent anti-leukemic activity. By converting AML blasts into immune activating and leukemia-antig...

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Bibliographic Details
Main Authors: Hazal Aslan Rejeski, Anne Hartz, Elias Rackl, Lin Li, Christoph Schwepcke, Kai Rejeski, Christoph Schmid, Andreas Rank, Jörg Schmohl, Doris Kraemer, Peter Bojko, Helga Maria Schmetzer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
blast modulation
dendritic cells
leukemia-derived dendritic cells
acute myeloid leukemia
PGE1
PGE2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1527961/full
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