Observation of choroidal and retinal changes in acute leukemia in remission using ultra-widefield optical coherence tomography angiography
Purpose: To observe choroidal and retinal changes in patients with acute leukemia in the remission stage using ultra-widefield swept-source optical coherence tomography angiography (SS-OCTA). Methods: This cross-sectional study included 10 patients with acute leukemia in the remission stage (10 eyes...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025001176 |
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| Summary: | Purpose: To observe choroidal and retinal changes in patients with acute leukemia in the remission stage using ultra-widefield swept-source optical coherence tomography angiography (SS-OCTA). Methods: This cross-sectional study included 10 patients with acute leukemia in the remission stage (10 eyes) and 12 age-matched healthy controls (12 eyes). Demographic data, disease duration, and laboratory parameters were recorded. SS-OCTA was used to scan the 12 × 12 mm macular area. The retina and choroid were divided into five concentric circles with diameters of 0–1 mm, 1–3 mm, 3–6 mm, 6–9 mm, and 9–12 mm. OCTA parameters, including the thicknesses of retina and choroid, the vessel densities of superficial vascular complexes (SVC) and deep vascular complexes (DVC), the three-dimensional choroidal vascularity volume (3D-CVV), the three-dimensional choroidal vascularity index (3D-CVI), and the flow area of choriocapillaries (CC), were compared. Results: The choroidal thickness of leukemia patients was thinner than that of the control in the 6–9 mm (P = 0.046) and 9–12 mm (P = 0.036) ranges. The 3D-CVV of patients with leukemia was significantly smaller than that in the control in the 1–3 mm (P = 0.024), 3–6 mm (P = 0.036), 6–9 mm (P = 0.038), and 9–12 mm (P = 0.028) ranges. There were no statistical differences in terms of retinal thickness, SVC, DVC, the 3D-CVI, and the flow area of CC between the groups across all ranges (all P > 0.05). Conclusion: Thinning of the choroid and a reduction in choroidal vessel volume could be observed in acute leukemia patients in remission using ultra-widefield SS-OCTA. |
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| ISSN: | 1572-1000 |