The multifaceted roles of cathepsins in immune and inflammatory responses: implications for cancer therapy, autoimmune diseases, and infectious diseases
Abstract The cathepsin family comprises lysosomal proteases that play essential roles in various physiological processes, including protein degradation, antigen presentation, apoptosis, and tissue remodeling. Dysregulation of cathepsin activity has been linked to a variety of pathological conditions...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-024-00711-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841559244921372672 |
|---|---|
| author | Kexin Zhao Yangqing Sun Shangwei Zhong Jun-Li Luo |
| author_facet | Kexin Zhao Yangqing Sun Shangwei Zhong Jun-Li Luo |
| author_sort | Kexin Zhao |
| collection | DOAJ |
| description | Abstract The cathepsin family comprises lysosomal proteases that play essential roles in various physiological processes, including protein degradation, antigen presentation, apoptosis, and tissue remodeling. Dysregulation of cathepsin activity has been linked to a variety of pathological conditions, such as cancer, autoimmune diseases, and neurodegenerative disorders. Understanding the functions of cathepsins is crucial for gaining insights into their roles in both health and disease, as well as for developing targeted therapeutic approaches. Emerging research underscores the significant involvement of cathepsins in immune cells, particularly T cells, macrophages, dendritic cells, and neutrophils, as well as their contribution to immune-related diseases. In this review, we systematically examine the impact of cathepsins on the immune system and their mechanistic roles in cancer, infectious diseases, autoimmune and neurodegenerative disorders, with the goal of identifying novel therapeutic strategies for these conditions. |
| format | Article |
| id | doaj-art-d5e9dd1dec30431d9c0e5c427b40dcec |
| institution | Kabale University |
| issn | 2050-7771 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj-art-d5e9dd1dec30431d9c0e5c427b40dcec2025-01-05T12:42:03ZengBMCBiomarker Research2050-77712024-12-0112111810.1186/s40364-024-00711-9The multifaceted roles of cathepsins in immune and inflammatory responses: implications for cancer therapy, autoimmune diseases, and infectious diseasesKexin Zhao0Yangqing Sun1Shangwei Zhong2Jun-Li Luo3The Cancer Research Institute and the Second Affiliated Hospital, Hengyang Medical School, University of South China (USC)Department of Oncology, Hunan Provincial People’s HospitalThe Cancer Research Institute and the Second Affiliated Hospital, Hengyang Medical School, University of South China (USC)The Cancer Research Institute and the Second Affiliated Hospital, Hengyang Medical School, University of South China (USC)Abstract The cathepsin family comprises lysosomal proteases that play essential roles in various physiological processes, including protein degradation, antigen presentation, apoptosis, and tissue remodeling. Dysregulation of cathepsin activity has been linked to a variety of pathological conditions, such as cancer, autoimmune diseases, and neurodegenerative disorders. Understanding the functions of cathepsins is crucial for gaining insights into their roles in both health and disease, as well as for developing targeted therapeutic approaches. Emerging research underscores the significant involvement of cathepsins in immune cells, particularly T cells, macrophages, dendritic cells, and neutrophils, as well as their contribution to immune-related diseases. In this review, we systematically examine the impact of cathepsins on the immune system and their mechanistic roles in cancer, infectious diseases, autoimmune and neurodegenerative disorders, with the goal of identifying novel therapeutic strategies for these conditions.https://doi.org/10.1186/s40364-024-00711-9Cathepsins in immune cellsCancer therapyAutoimmune diseasesInfectious diseases |
| spellingShingle | Kexin Zhao Yangqing Sun Shangwei Zhong Jun-Li Luo The multifaceted roles of cathepsins in immune and inflammatory responses: implications for cancer therapy, autoimmune diseases, and infectious diseases Biomarker Research Cathepsins in immune cells Cancer therapy Autoimmune diseases Infectious diseases |
| title | The multifaceted roles of cathepsins in immune and inflammatory responses: implications for cancer therapy, autoimmune diseases, and infectious diseases |
| title_full | The multifaceted roles of cathepsins in immune and inflammatory responses: implications for cancer therapy, autoimmune diseases, and infectious diseases |
| title_fullStr | The multifaceted roles of cathepsins in immune and inflammatory responses: implications for cancer therapy, autoimmune diseases, and infectious diseases |
| title_full_unstemmed | The multifaceted roles of cathepsins in immune and inflammatory responses: implications for cancer therapy, autoimmune diseases, and infectious diseases |
| title_short | The multifaceted roles of cathepsins in immune and inflammatory responses: implications for cancer therapy, autoimmune diseases, and infectious diseases |
| title_sort | multifaceted roles of cathepsins in immune and inflammatory responses implications for cancer therapy autoimmune diseases and infectious diseases |
| topic | Cathepsins in immune cells Cancer therapy Autoimmune diseases Infectious diseases |
| url | https://doi.org/10.1186/s40364-024-00711-9 |
| work_keys_str_mv | AT kexinzhao themultifacetedrolesofcathepsinsinimmuneandinflammatoryresponsesimplicationsforcancertherapyautoimmunediseasesandinfectiousdiseases AT yangqingsun themultifacetedrolesofcathepsinsinimmuneandinflammatoryresponsesimplicationsforcancertherapyautoimmunediseasesandinfectiousdiseases AT shangweizhong themultifacetedrolesofcathepsinsinimmuneandinflammatoryresponsesimplicationsforcancertherapyautoimmunediseasesandinfectiousdiseases AT junliluo themultifacetedrolesofcathepsinsinimmuneandinflammatoryresponsesimplicationsforcancertherapyautoimmunediseasesandinfectiousdiseases AT kexinzhao multifacetedrolesofcathepsinsinimmuneandinflammatoryresponsesimplicationsforcancertherapyautoimmunediseasesandinfectiousdiseases AT yangqingsun multifacetedrolesofcathepsinsinimmuneandinflammatoryresponsesimplicationsforcancertherapyautoimmunediseasesandinfectiousdiseases AT shangweizhong multifacetedrolesofcathepsinsinimmuneandinflammatoryresponsesimplicationsforcancertherapyautoimmunediseasesandinfectiousdiseases AT junliluo multifacetedrolesofcathepsinsinimmuneandinflammatoryresponsesimplicationsforcancertherapyautoimmunediseasesandinfectiousdiseases |