Early sublingual microcirculation changes in patients with septic shock at different altitudes
Objective To observe the changes of early sublingual microcirculation in patients with septic shock at different altitudes, and to provide reference for clinical treatment of patients with septic shock at high altitude. Methods From September 2021 to March 2023, patients with septic shock at high...
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The Editorial Department of Chinese Journal of Clinical Research
2024-11-01
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| author | HE Zongzhao, WANG Hao*, GUO Litao, MA Siqing, XIANG Hui, ZHENG Xing |
| author_facet | HE Zongzhao, WANG Hao*, GUO Litao, MA Siqing, XIANG Hui, ZHENG Xing |
| author_sort | HE Zongzhao, WANG Hao*, GUO Litao, MA Siqing, XIANG Hui, ZHENG Xing |
| collection | DOAJ |
| description | Objective To observe the changes of early sublingual microcirculation in patients with septic shock at different altitudes, and to provide reference for clinical treatment of patients with septic shock at high altitude. Methods From September 2021 to March 2023, patients with septic shock at high altitude (Xining, 28 cases) and at low altitude (Wuhan, 26 cases) were selected as study subjects in the Department of Intensive Care Medicine of Qinghai Provincial People's Hospital and Zhongnan Hospital of Wuhan University. The basal data, blood cell counts, inflammation indexes, and coagulation function indexes ［prothrombin time (PT), thrombin time (TT), and international normalized ratio (INR)］ were recoded. The sidestream dark field (SDF) monitoring technique was used to monitor sublingual microcirculation indexes ［total vascular density (TVD), perfusion vascular density (PVD), proportion of perfused vessels (PPV), microfluidic flow index (MFI), and heterogeneity index (HI)］. The changes of sublingual microcirculation in patients at different altitudes were compared. Results There was no statistically significant difference in the comparison of basic information, inflammation indexes and INR between patients with septic shock in the two regions (P＞0.05). However, the PT［19.65 (16.80, 31.50) s vs 14.60 (12.92, 18.65) s］and TT ［20.45 (18.78, 23.18) s vs 15.65 (13.82, 19.55) s］ were significantly longer in the high-altitude region compared to the low-altitude region (P＜0.05). Compared with patients in low altitude, TVD［17.37 (13.61, 19.65) mm/mm2 vs 14.18 (13.10, 16.07) mm/mm2］ and HI［1.60 (0.55, 3.00) vs 0.71 (0.44, 1.05)］ were significantly higher, while PVD［3.29 (1.83,11.24) mm/mm2 vs 12.66 (9.39,14.87) mm/mm2］、PPV［22.55% (10.28%, 77.15%) vs 87.85% (72.02%, 94.65%)］, and MFI［0.87 (0.63, 1.95) vs 2.50 (2.24, 2.71)］ were significantly lower in high altitude region (P＜0.05). Conclusion The disturbance of sublingual microcirculation in patients with septic shock at high altitude is more pronounced compared to those at low altitude. Specifically, there is a significant reduction in PVD, PPV, and MFI, while the HI of perfusion distribution becomes more prominent.
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| format | Article |
| id | doaj-art-d5afdab6d65d454184899bade0f6dbad |
| institution | Kabale University |
| issn | 1674-8182 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj-art-d5afdab6d65d454184899bade0f6dbad2024-11-25T07:03:48ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822024-11-0137111695169910.13429/j.cnki.cjcr.2024.11.010Early sublingual microcirculation changes in patients with septic shock at different altitudesHE Zongzhao, WANG Hao*, GUO Litao, MA Siqing, XIANG Hui, ZHENG Xing 0*Department of Anesthesiology, Qinghai Provincial People's Hospital, Xining, Qinghai 810000, ChinaObjective To observe the changes of early sublingual microcirculation in patients with septic shock at different altitudes, and to provide reference for clinical treatment of patients with septic shock at high altitude. Methods From September 2021 to March 2023, patients with septic shock at high altitude (Xining, 28 cases) and at low altitude (Wuhan, 26 cases) were selected as study subjects in the Department of Intensive Care Medicine of Qinghai Provincial People's Hospital and Zhongnan Hospital of Wuhan University. The basal data, blood cell counts, inflammation indexes, and coagulation function indexes ［prothrombin time (PT), thrombin time (TT), and international normalized ratio (INR)］ were recoded. The sidestream dark field (SDF) monitoring technique was used to monitor sublingual microcirculation indexes ［total vascular density (TVD), perfusion vascular density (PVD), proportion of perfused vessels (PPV), microfluidic flow index (MFI), and heterogeneity index (HI)］. The changes of sublingual microcirculation in patients at different altitudes were compared. Results There was no statistically significant difference in the comparison of basic information, inflammation indexes and INR between patients with septic shock in the two regions (P＞0.05). However, the PT［19.65 (16.80, 31.50) s vs 14.60 (12.92, 18.65) s］and TT ［20.45 (18.78, 23.18) s vs 15.65 (13.82, 19.55) s］ were significantly longer in the high-altitude region compared to the low-altitude region (P＜0.05). Compared with patients in low altitude, TVD［17.37 (13.61, 19.65) mm/mm2 vs 14.18 (13.10, 16.07) mm/mm2］ and HI［1.60 (0.55, 3.00) vs 0.71 (0.44, 1.05)］ were significantly higher, while PVD［3.29 (1.83,11.24) mm/mm2 vs 12.66 (9.39,14.87) mm/mm2］、PPV［22.55% (10.28%, 77.15%) vs 87.85% (72.02%, 94.65%)］, and MFI［0.87 (0.63, 1.95) vs 2.50 (2.24, 2.71)］ were significantly lower in high altitude region (P＜0.05). Conclusion The disturbance of sublingual microcirculation in patients with septic shock at high altitude is more pronounced compared to those at low altitude. Specifically, there is a significant reduction in PVD, PPV, and MFI, while the HI of perfusion distribution becomes more prominent. http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241110sepsis， septic shock， altitudes， sublingual microcirculation， vascular density， coagulation function |
| spellingShingle | HE Zongzhao, WANG Hao*, GUO Litao, MA Siqing, XIANG Hui, ZHENG Xing Early sublingual microcirculation changes in patients with septic shock at different altitudes Zhongguo linchuang yanjiu sepsis， septic shock， altitudes， sublingual microcirculation， vascular density， coagulation function |
| title | Early sublingual microcirculation changes in patients with septic shock at different altitudes |
| title_full | Early sublingual microcirculation changes in patients with septic shock at different altitudes |
| title_fullStr | Early sublingual microcirculation changes in patients with septic shock at different altitudes |
| title_full_unstemmed | Early sublingual microcirculation changes in patients with septic shock at different altitudes |
| title_short | Early sublingual microcirculation changes in patients with septic shock at different altitudes |
| title_sort | early sublingual microcirculation changes in patients with septic shock at different altitudes |
| topic | sepsis， septic shock， altitudes， sublingual microcirculation， vascular density， coagulation function |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241110 |
| work_keys_str_mv | AT hezongzhaowanghaoguolitaomasiqingxianghuizhengxing earlysublingualmicrocirculationchangesinpatientswithsepticshockatdifferentaltitudes |