High‐throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

High‐throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

Formalin‐fixed, paraffin‐embedded (FFPE), biobanked tissue samples offer an invaluable resource for clinical and biomarker research. Here, we developed a pressure cycling technology (PCT)‐SWATH mass spectrometry workflow to analyze FFPE tissue proteomes and applied it to the stratification of prosta...

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Main Authors: Yi Zhu, Tobias Weiss, Qiushi Zhang, Rui Sun, Bo Wang, Xiao Yi, Zhicheng Wu, Huanhuan Gao, Xue Cai, Guan Ruan, Tiansheng Zhu, Chao Xu, Sai Lou, Xiaoyan Yu, Ludovic Gillet, Peter Blattmann, Karim Saba, Christian D. Fankhauser, Michael B. Schmid, Dorothea Rutishauser, Jelena Ljubicic, Ailsa Christiansen, Christine Fritz, Niels J. Rupp, Cedric Poyet, Elisabeth Rushing, Michael Weller, Patrick Roth, Eugenia Haralambieva, Silvia Hofer, Chen Chen, Wolfram Jochum, Xiaofei Gao, Xiaodong Teng, Lirong Chen, Qing Zhong, Peter J. Wild, Ruedi Aebersold, Tiannan Guo
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Molecular Oncology
Subjects:
biomarker
FFPE
pressure cycling technology
proteome
SWATH
tumor
Online Access:https://doi.org/10.1002/1878-0261.12570
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https://doi.org/10.1002/1878-0261.12570

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