ANTIBIOTIC ACTIVITIES OF MUSHROOM EXTRACTS AGAINST ANTIBIOTIC -RESISTANT ORGANISMS
Antibiotic resistance accompanied by high rate of chemotherapeutic failure has paved way into the assessment and investigation of medicinal plants in order to assess their antimicrobial potency. This research was aimed at analyzing the antibiotic activities of mushrooms extracts against multi-drug...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Biosciences
2025-06-01
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| Series: | The Bioscientist |
| Subjects: | |
| Online Access: | http://bioscientistjournal.com/index.php/The_Bioscientist/article/view/182 |
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| Summary: | Antibiotic resistance accompanied by high rate of chemotherapeutic failure has paved way into the assessment and investigation of medicinal plants in order to assess their antimicrobial potency. This research was aimed at analyzing the antibiotic activities of mushrooms extracts against multi-drug resistant isolates from hospital. The identification of the microorganisms and antibiotic resistant status were investigated using Standard Microbiological, Biochemical and antibiotic sensitivity tests. The Aqueous and Ethanolic extracts of two (2) mushroom species Agaricus bisporus and Omphalotus palmatus were obtained and analyzed for their quantitative and qualitative phytochemical contents. The results revealed that the resistant index of Staphylococcus sp and Klebsiella sp was 0.6 and 0.4 respectively. The bioactive compounds contained in the mushroom extracts include different quantities of Alkaloids, Proteins, Flavonoids, reducing sugars, Tannins, Terpenoids, Saponin and Cardiac glycoside. All mushroom extracts were active against test bacteria but at varying degrees with the aqueous extract of the mixed mushroom extracts being the most active. It was also observed that the Minimum Inhibitory Concentration (MIC) of ethanolic extract of Omphalotus palmatus and mixed aqueous extract of both mushrooms were at 25mg/ml concentration while that of aqueous extract of Agaricus bisporus, aqueous extract of Omphalotus palmatus and ethanolic extract of mixed mushroom samples were at 50mg/ml. The antimicrobial metabolites produced by mushrooms and their synergistic actions can be harnessed in the treatment of diseases.
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| ISSN: | 2630-7103 2630-7111 |