Cancer cells sense solid stress to enhance metastasis by CKAP4 phase separation-mediated microtubule branching

Cancer cells sense solid stress to enhance metastasis by CKAP4 phase separation-mediated microtubule branching

Abstract Solid stress, originating from rigid and elastic components of extracellular matrix and cells, is a typical physical hallmark of tumors. Mounting evidence indicates that elevated solid stress drives metastasis and affects prognosis. However, the molecular mechanism of how cancer cells sense...

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Main Authors: Xing Sun, Yangyang Zhou, Shengjie Sun, Siyuan Qiu, Menglan Peng, Han Gong, Junxiao Guo, Chengcai Wen, Yibin Zhang, Yifang Xie, Hui Li, Long Liang, Guoyan Luo, Wencan Wu, Jing Liu, Weihong Tan, Mao Ye
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-024-00737-1
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