Venetoclax and Azacitidine Combination is an Effective Salvage Regimen for Fit Patients with IDH-2-mutated Acute Myeloid Leukemia Refractory to Conventional Induction Chemotherapy
Acute myeloid leukemia (AML) constitutes a heterogeneous group of clonal myeloid neoplasms that is associated with a large number of recurrent genetic abnormalities. Mutations in IDH2 gene can be found in nearly 10% of newly diagnosed AML patients. The impact of IDH2 mutations on prognosis in the ab...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Applied Hematology |
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| Online Access: | https://journals.lww.com/10.4103/joah.joah_97_24 |
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| author | Musa Fares Alzahrani |
| author_facet | Musa Fares Alzahrani |
| author_sort | Musa Fares Alzahrani |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) constitutes a heterogeneous group of clonal myeloid neoplasms that is associated with a large number of recurrent genetic abnormalities. Mutations in IDH2 gene can be found in nearly 10% of newly diagnosed AML patients. The impact of IDH2 mutations on prognosis in the absence of other genetic abnormalities remains to be unclear in fit patients although recently believed to be favorable in less fit patients receiving less intensive therapy. Enasidenib, which is an IDH2 inhibitor, was recently developed, but it is currently not widely available and it is only approved in the relapsed or refractory setting. Moreover, fit patients with AML who fail to respond to conventional induction chemotherapy represent a high-risk group in whom the only potential cure is allogeneic stem cell transplantation (AlloSCT), which is ideally performed after achievement of complete remission following treatment with a salvage regimen. Previous studies have shown efficacy of venetoclax combination with azacitidine (VenAza) in newly diagnosed unfit patients. It is still unknown if VenAza is an effective salvage regimen for fit IDH2-mutated AML patients who fail to respond to traditional chemotherapy. Here, we report two cases with IDH2-mutated AML, both of whom salvaged successfully with VenAza, which allowed bridging to the definitive treatment of AlloSCT. |
| format | Article |
| id | doaj-art-d580f8f25ece433694b3fb2cec21862c |
| institution | Kabale University |
| issn | 1658-5127 2454-6976 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Applied Hematology |
| spelling | doaj-art-d580f8f25ece433694b3fb2cec21862c2025-01-10T11:14:56ZengWolters Kluwer Medknow PublicationsJournal of Applied Hematology1658-51272454-69762024-12-0115432633010.4103/joah.joah_97_24Venetoclax and Azacitidine Combination is an Effective Salvage Regimen for Fit Patients with IDH-2-mutated Acute Myeloid Leukemia Refractory to Conventional Induction ChemotherapyMusa Fares AlzahraniAcute myeloid leukemia (AML) constitutes a heterogeneous group of clonal myeloid neoplasms that is associated with a large number of recurrent genetic abnormalities. Mutations in IDH2 gene can be found in nearly 10% of newly diagnosed AML patients. The impact of IDH2 mutations on prognosis in the absence of other genetic abnormalities remains to be unclear in fit patients although recently believed to be favorable in less fit patients receiving less intensive therapy. Enasidenib, which is an IDH2 inhibitor, was recently developed, but it is currently not widely available and it is only approved in the relapsed or refractory setting. Moreover, fit patients with AML who fail to respond to conventional induction chemotherapy represent a high-risk group in whom the only potential cure is allogeneic stem cell transplantation (AlloSCT), which is ideally performed after achievement of complete remission following treatment with a salvage regimen. Previous studies have shown efficacy of venetoclax combination with azacitidine (VenAza) in newly diagnosed unfit patients. It is still unknown if VenAza is an effective salvage regimen for fit IDH2-mutated AML patients who fail to respond to traditional chemotherapy. Here, we report two cases with IDH2-mutated AML, both of whom salvaged successfully with VenAza, which allowed bridging to the definitive treatment of AlloSCT.https://journals.lww.com/10.4103/joah.joah_97_24acute myeloid leukemiaidh-2salvagevenetoclax |
| spellingShingle | Musa Fares Alzahrani Venetoclax and Azacitidine Combination is an Effective Salvage Regimen for Fit Patients with IDH-2-mutated Acute Myeloid Leukemia Refractory to Conventional Induction Chemotherapy Journal of Applied Hematology acute myeloid leukemia idh-2 salvage venetoclax |
| title | Venetoclax and Azacitidine Combination is an Effective Salvage Regimen for Fit Patients with IDH-2-mutated Acute Myeloid Leukemia Refractory to Conventional Induction Chemotherapy |
| title_full | Venetoclax and Azacitidine Combination is an Effective Salvage Regimen for Fit Patients with IDH-2-mutated Acute Myeloid Leukemia Refractory to Conventional Induction Chemotherapy |
| title_fullStr | Venetoclax and Azacitidine Combination is an Effective Salvage Regimen for Fit Patients with IDH-2-mutated Acute Myeloid Leukemia Refractory to Conventional Induction Chemotherapy |
| title_full_unstemmed | Venetoclax and Azacitidine Combination is an Effective Salvage Regimen for Fit Patients with IDH-2-mutated Acute Myeloid Leukemia Refractory to Conventional Induction Chemotherapy |
| title_short | Venetoclax and Azacitidine Combination is an Effective Salvage Regimen for Fit Patients with IDH-2-mutated Acute Myeloid Leukemia Refractory to Conventional Induction Chemotherapy |
| title_sort | venetoclax and azacitidine combination is an effective salvage regimen for fit patients with idh 2 mutated acute myeloid leukemia refractory to conventional induction chemotherapy |
| topic | acute myeloid leukemia idh-2 salvage venetoclax |
| url | https://journals.lww.com/10.4103/joah.joah_97_24 |
| work_keys_str_mv | AT musafaresalzahrani venetoclaxandazacitidinecombinationisaneffectivesalvageregimenforfitpatientswithidh2mutatedacutemyeloidleukemiarefractorytoconventionalinductionchemotherapy |