Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility

Mouse ZGRF1 helicase facilitates DNA repair and maintains efficient fertility

The recently characterised human ZGRF1 helicase promotes genomic stability by facilitating DNA interstrand crosslink repair. In its absence, human cells exhibit greater sensitivity towards anti-cancer drugs such as mitomycin C and camptothecin. Moreover, the downregulation of ZGRF1 expression is ass...

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Bibliographic Details
Main Authors: Ernest Wee Kiat Lim, Smaragda Kompocholi, André Brannvoll, K. Stine V. Bagge, Jennifer R. Gruhn, Javier Martin-Gonzalez, Eliene Albers, Ian D. Hickson, Andrés López-Contreras, Michael Lisby
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
ZGRF1
DNA helicase
Interstrand crosslinks
DNA repair
Homologous recombination
Mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025003597
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