Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review
This review paper explores the cutting-edge advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence worldwide that can lead to joint breakdown at a later stage of the disease, necessitating immediate intervention to prevent...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-01-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X2400392X |
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| author | Fariba Hashemi-Afzal Hooman Fallahi Fatemeh Bagheri Maurice N. Collins Mohamadreza Baghaban Eslaminejad Hermann Seitz |
| author_facet | Fariba Hashemi-Afzal Hooman Fallahi Fatemeh Bagheri Maurice N. Collins Mohamadreza Baghaban Eslaminejad Hermann Seitz |
| author_sort | Fariba Hashemi-Afzal |
| collection | DOAJ |
| description | This review paper explores the cutting-edge advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence worldwide that can lead to joint breakdown at a later stage of the disease, necessitating immediate intervention to prevent progressive degeneration of cartilage. Decades of research into the biomedical applications of hydrogels have revealed their tremendous potential, particularly in soft tissue engineering, including CR. Hydrogels are highly tunable and can be designed to meet the key criteria needed for a template in CR. This paper aims to identify those criteria, including the hydrogel components, mechanical properties, biodegradability, structural design, and integration capability with the adjacent native tissue and delves into the benefits that CR can obtain through appropriate design. Stratified-structural hydrogels that emulate the native cartilage structure, as well as the impact of environmental stimuli on the regeneration outcome, have also been discussed. By examining recent advances and emerging techniques, this paper offers valuable insights into developing effective hydrogel-based therapies for AC repair. |
| format | Article |
| id | doaj-art-d55a1d364b384918ae1c44e018b7a07f |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-d55a1d364b384918ae1c44e018b7a07f2024-11-25T04:41:30ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-01-0143131Advancements in hydrogel design for articular cartilage regeneration: A comprehensive reviewFariba Hashemi-Afzal0Hooman Fallahi1Fatemeh Bagheri2Maurice N. Collins3Mohamadreza Baghaban Eslaminejad4Hermann Seitz5Biotechnology Department, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, 14115-111, IranBiomedical Engineering Department, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, 14115-111, Iran; School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, 19104 USABiotechnology Department, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran, 14115-111, Iran; Corresponding author.School of Engineering, Bernal Institute and Health Research Institute, University of Limerick, Limerick V94 T9PX, IrelandDepartment of Stem Cells and Developmental Biology, Cell Sciences Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, 16635-148, Iran; Corresponding author.Faculty of Mechanical Engineering and Marine Technology, University of Rostock, Justus-von-Liebig-Weg 6, 18059 Rostock, Germany; Department Life, Light & Matter, University of Rostock, Albert-Einstein-Straße 25, 18059 Rostock, Germany; Corresponding author.This review paper explores the cutting-edge advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence worldwide that can lead to joint breakdown at a later stage of the disease, necessitating immediate intervention to prevent progressive degeneration of cartilage. Decades of research into the biomedical applications of hydrogels have revealed their tremendous potential, particularly in soft tissue engineering, including CR. Hydrogels are highly tunable and can be designed to meet the key criteria needed for a template in CR. This paper aims to identify those criteria, including the hydrogel components, mechanical properties, biodegradability, structural design, and integration capability with the adjacent native tissue and delves into the benefits that CR can obtain through appropriate design. Stratified-structural hydrogels that emulate the native cartilage structure, as well as the impact of environmental stimuli on the regeneration outcome, have also been discussed. By examining recent advances and emerging techniques, this paper offers valuable insights into developing effective hydrogel-based therapies for AC repair.http://www.sciencedirect.com/science/article/pii/S2452199X2400392XArticular cartilageHydrogel designEnvironmental stimuliTissue engineering |
| spellingShingle | Fariba Hashemi-Afzal Hooman Fallahi Fatemeh Bagheri Maurice N. Collins Mohamadreza Baghaban Eslaminejad Hermann Seitz Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review Bioactive Materials Articular cartilage Hydrogel design Environmental stimuli Tissue engineering |
| title | Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review |
| title_full | Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review |
| title_fullStr | Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review |
| title_full_unstemmed | Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review |
| title_short | Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review |
| title_sort | advancements in hydrogel design for articular cartilage regeneration a comprehensive review |
| topic | Articular cartilage Hydrogel design Environmental stimuli Tissue engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X2400392X |
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