Placental Growth Factor as a Diagnostic Glycoprotein in Preeclampsia
Angiogenic factor imbalance, such as that caused by placental growth factor (PLGF), is a feature of preeclampsia. However, the connection amony PLGF, clinical, laboratory indicators and the severity of preeclampsia is not entirely understood. Ninety subjects were incorporated in this study (The age...
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College of science, university of Diyala
2024-07-01
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| author | Shaima Sh. AL-kilan Ekhlas Abdallah Hassan |
| author_facet | Shaima Sh. AL-kilan Ekhlas Abdallah Hassan |
| author_sort | Shaima Sh. AL-kilan |
| collection | DOAJ |
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Angiogenic factor imbalance, such as that caused by placental growth factor (PLGF), is a feature of preeclampsia. However, the connection amony PLGF, clinical, laboratory indicators and the severity of preeclampsia is not entirely understood. Ninety subjects were incorporated in this study (The age range 17-40years),( 30 ) were healthy pregnant with mean age (26.57±1.07 ). (30) Mild Preeclampsia cases with mean age (30.42±0.78) and (30) sever PE with mean age (33.32±1.09) wherever all women were more than 20 weeks of pregnancy. Mean blood pressure and level of proteinuria were used as indicators of the severity of the disease. ELISA was used to measure the levels of PLGF in the serum. Serum lipid profile were measured by enzymatic methods. The qualitative dip-stick technique was used to assess the amount of urine protein. A substantial difference between the PE group's serum PLGF concentration and that of the healthy subjects (p= 0.001) could be seen. Serum PLGF concentrations of patients with mild PE and those with severe PE differed significantly. Additionally, there were strong positive relationships between the serum PLGF concentration and the systolic BP and proteinuria serum PLGF levels, biochemical indicators, and other factors, however, did not significantly correlate. The diagnostic accuracy in distinguishing PE from the healthy patient group was good thanks to the excellent area under the curve (AUC = 0.83, p = 0.0001) In conclusion, Levels of PLGF in area of PE patients were decreaed. PLGF was significantly correlated with PE patients.
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| format | Article |
| id | doaj-art-d554a7cf25914bf88dfa8a029f02c77b |
| institution | Kabale University |
| issn | 2958-4612 2959-5568 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | College of science, university of Diyala |
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| series | Academic Science Journal |
| spelling | doaj-art-d554a7cf25914bf88dfa8a029f02c77b2024-11-19T10:00:12ZengCollege of science, university of DiyalaAcademic Science Journal2958-46122959-55682024-07-012310.24237/ASJ.02.02.757BPlacental Growth Factor as a Diagnostic Glycoprotein in PreeclampsiaShaima Sh. AL-kilanEkhlas Abdallah Hassan Angiogenic factor imbalance, such as that caused by placental growth factor (PLGF), is a feature of preeclampsia. However, the connection amony PLGF, clinical, laboratory indicators and the severity of preeclampsia is not entirely understood. Ninety subjects were incorporated in this study (The age range 17-40years),( 30 ) were healthy pregnant with mean age (26.57±1.07 ). (30) Mild Preeclampsia cases with mean age (30.42±0.78) and (30) sever PE with mean age (33.32±1.09) wherever all women were more than 20 weeks of pregnancy. Mean blood pressure and level of proteinuria were used as indicators of the severity of the disease. ELISA was used to measure the levels of PLGF in the serum. Serum lipid profile were measured by enzymatic methods. The qualitative dip-stick technique was used to assess the amount of urine protein. A substantial difference between the PE group's serum PLGF concentration and that of the healthy subjects (p= 0.001) could be seen. Serum PLGF concentrations of patients with mild PE and those with severe PE differed significantly. Additionally, there were strong positive relationships between the serum PLGF concentration and the systolic BP and proteinuria serum PLGF levels, biochemical indicators, and other factors, however, did not significantly correlate. The diagnostic accuracy in distinguishing PE from the healthy patient group was good thanks to the excellent area under the curve (AUC = 0.83, p = 0.0001) In conclusion, Levels of PLGF in area of PE patients were decreaed. PLGF was significantly correlated with PE patients. https://acadscij.uodiyala.edu.iq/index.php/Home/article/view/508placental growth factor, preeclampsia, proteinuria, blood pressure. |
| spellingShingle | Shaima Sh. AL-kilan Ekhlas Abdallah Hassan Placental Growth Factor as a Diagnostic Glycoprotein in Preeclampsia Academic Science Journal placental growth factor, preeclampsia, proteinuria, blood pressure. |
| title | Placental Growth Factor as a Diagnostic Glycoprotein in Preeclampsia |
| title_full | Placental Growth Factor as a Diagnostic Glycoprotein in Preeclampsia |
| title_fullStr | Placental Growth Factor as a Diagnostic Glycoprotein in Preeclampsia |
| title_full_unstemmed | Placental Growth Factor as a Diagnostic Glycoprotein in Preeclampsia |
| title_short | Placental Growth Factor as a Diagnostic Glycoprotein in Preeclampsia |
| title_sort | placental growth factor as a diagnostic glycoprotein in preeclampsia |
| topic | placental growth factor, preeclampsia, proteinuria, blood pressure. |
| url | https://acadscij.uodiyala.edu.iq/index.php/Home/article/view/508 |
| work_keys_str_mv | AT shaimashalkilan placentalgrowthfactorasadiagnosticglycoproteininpreeclampsia AT ekhlasabdallahhassan placentalgrowthfactorasadiagnosticglycoproteininpreeclampsia |