Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance

Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance

As a metabolic center, the liver prevents inappropriate immune responses to abundant dietary antigens within the liver that could result in liver injury. This self-preservation mechanism can however decrease the efficiency of immunosurveillance of malignant cells by CD8 T cells. Hepatocellular carci...

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Bibliographic Details
Main Authors: Kimberly N. Kremer, Hadeel A. Khammash, Anjelica M. Miranda, Lauren N. Rutt, Shannon M. Twardy, Paige E. Anton, Margaret L. Campbell, Christian Garza-Ortiz, David J. Orlicky, Roberta Pelanda, Rebecca L. McCullough, Raul M. Torres
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
liver sinusoidal endothelial cells
T cell exhaustion
hepatocellular carcinoma
T cell
Immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497788/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1497788/full

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