Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks

Abstract In chronic lymphocytic leukemia (CLL), a diverse set of genetic mutations is embedded in a deregulated epigenetic landscape that drives cancerogenesis. To elucidate the role of aberrant chromatin features, we mapped DNA methylation, seven histone modifications, nucleosome positions, chromat...

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Bibliographic Details
Main Authors: Jan‐Philipp Mallm, Murat Iskar, Naveed Ishaque, Lara C Klett, Sabrina J Kugler, Jose M Muino, Vladimir B Teif, Alexandra M Poos, Sebastian Großmann, Fabian Erdel, Daniele Tavernari, Sandra D Koser, Sabrina Schumacher, Benedikt Brors, Rainer König, Daniel Remondini, Martin Vingron, Stephan Stilgenbauer, Peter Lichter, Marc Zapatka, Daniel Mertens, Karsten Rippe
Format: Article
Language:English
Published: Springer Nature 2019-05-01
Series:Molecular Systems Biology
Subjects:
bivalent promoter
DNA methylation
enhancer
gene regulatory networks
histone modifications
Online Access:https://doi.org/10.15252/msb.20188339
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