Elevated KRAS protein level is associated with better survival in pancreatic cancer

Elevated KRAS protein level is associated with better survival in pancreatic cancer

Abstract Background Activating somatic KRAS mutations in hotspot loci occur almost universally (> 95%) in pancreatic ductal adenocarcinoma (PDAC). Both the presence of a KRAS mutation and high mRNA expression levels of KRAS in tumor tissue have been associated with worse outcome. Less is known ab...

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Main Authors: S. M. Stålberg, L. Silwal-Pandit, J. Hamfjord, D. J. H. Nebdal, J. Lehtiö, O. C. Lingjærde, B. S. Skålhegg, E. H. Kure
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Pancreatic cancer
PDAC
KRAS protein level
KRAS mRNA expression
KRAS mutation
Online Access:https://doi.org/10.1186/s12885-025-14461-w
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