Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies
The ongoing quest to discover effective treatments for diseases remains a significant challenge for the scientific community. Multicomponent reactions (MCRs) have emerged as powerful tools in accelerating drug discovery, enabling the rapid generation of chemical libraries with high diversity in a ti...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2024-12-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.20.261 |
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| _version_ | 1841557378048196608 |
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| author | Lucía Campos-Prieto Aitor García-Rey Eddy Sotelo Ana Mallo-Abreu |
| author_facet | Lucía Campos-Prieto Aitor García-Rey Eddy Sotelo Ana Mallo-Abreu |
| author_sort | Lucía Campos-Prieto |
| collection | DOAJ |
| description | The ongoing quest to discover effective treatments for diseases remains a significant challenge for the scientific community. Multicomponent reactions (MCRs) have emerged as powerful tools in accelerating drug discovery, enabling the rapid generation of chemical libraries with high diversity in a time-efficient and environmentally sustainable manner. In this review, we focus on central nervous system (CNS) disorders, particularly Alzheimer's disease, Parkinson's disease, schizophrenia, depression, and epilepsy, where MCRs have contributed to the development of promising ligands in recent years. Rather than providing an exhaustive overview, this review aims to highlight key studies that address major CNS pathologies, relevant drug targets, and various MCR approaches. We have carefully selected representative articles and apologize to the authors whose important contributions may not be included. By concentrating on these pivotal studies, we strive to offer a clear and concise perspective on current research trends and breakthroughs in this field. |
| format | Article |
| id | doaj-art-d514428494964c9ea2918fed5266ba08 |
| institution | Kabale University |
| issn | 1860-5397 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj-art-d514428494964c9ea2918fed5266ba082025-01-06T12:27:36ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972024-12-012013151317310.3762/bjoc.20.2611860-5397-20-261Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologiesLucía Campos-Prieto0Aitor García-Rey1Eddy Sotelo2Ana Mallo-Abreu3Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain Laboratory of Medicinal Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain The ongoing quest to discover effective treatments for diseases remains a significant challenge for the scientific community. Multicomponent reactions (MCRs) have emerged as powerful tools in accelerating drug discovery, enabling the rapid generation of chemical libraries with high diversity in a time-efficient and environmentally sustainable manner. In this review, we focus on central nervous system (CNS) disorders, particularly Alzheimer's disease, Parkinson's disease, schizophrenia, depression, and epilepsy, where MCRs have contributed to the development of promising ligands in recent years. Rather than providing an exhaustive overview, this review aims to highlight key studies that address major CNS pathologies, relevant drug targets, and various MCR approaches. We have carefully selected representative articles and apologize to the authors whose important contributions may not be included. By concentrating on these pivotal studies, we strive to offer a clear and concise perspective on current research trends and breakthroughs in this field.https://doi.org/10.3762/bjoc.20.261alzheimerdepressionepilepsymulticomponent reactionsparkinsonschizophrenia |
| spellingShingle | Lucía Campos-Prieto Aitor García-Rey Eddy Sotelo Ana Mallo-Abreu Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies Beilstein Journal of Organic Chemistry alzheimer depression epilepsy multicomponent reactions parkinson schizophrenia |
| title | Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies |
| title_full | Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies |
| title_fullStr | Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies |
| title_full_unstemmed | Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies |
| title_short | Multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies |
| title_sort | multicomponent reactions driving the discovery and optimization of agents targeting central nervous system pathologies |
| topic | alzheimer depression epilepsy multicomponent reactions parkinson schizophrenia |
| url | https://doi.org/10.3762/bjoc.20.261 |
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