PARP inhibition radiosensitizes BRCA1 wildtype and mutated breast cancer to proton therapy

PARP inhibition radiosensitizes BRCA1 wildtype and mutated breast cancer to proton therapy

Abstract Aggressive breast cancers often fail or acquire resistance to radiotherapy. To develop new strategies to improve the outcome of aggressive breast cancer patients, we studied how PARP inhibition radiosensitizes breast cancer models to proton therapy, which is a radiotherapy modality that gen...

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Bibliographic Details
Main Authors: Mariam Ben Kacem, Scott J. Bright, Emma Moran, David B. Flint, David K. J. Martinus, Broderick X. Turner, Ilsa Qureshi, Rishab Kolachina, Mandira Manandhar, Poliana C. Marinello, Simona F. Shaitelman, Gabriel O. Sawakuchi
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
DNA repair inhibitor
PARP inhibitor
Radiosensitization
Proton therapy
Radiobiology
Radiotherapy
Online Access:https://doi.org/10.1038/s41598-024-81914-w
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