The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5

The ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5

The autosomal recessive disease ataxia-telangiectasia (A-T) presents with cerebellar degeneration, immunodeficiency, radiosensitivity, capillary dilatations, and pulmonary infections. Most symptoms outside the nervous system can be explained by failures of the disease protein ATM as a Ser/Thr-kinase...

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Main Authors: Marina Reichlmeir, Ruth Pia Duecker, Hanna Röhrich, Jana Key, Ralf Schubert, Kathryn Abell, Anthony P. Possemato, Matthew P. Stokes, Georg Auburger
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Neurobiology of Disease
Subjects:
PhosphoScan®
Immobilized metal affinity chromatography
Label-free mass spectrometry
Co-immunoprecipitation
Sodium arsenite
Chloroquine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003589
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