Clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland: A single‐center, 11‐year experience
Abstract Background Metastasis to the thyroid gland from lung adenocarcinoma is rare and challenging to diagnose due to similar histopathological features. This study aimed to analyze the clinicopathological characteristics of and treatment strategies for lung adenocarcinoma metastasis to the thyroi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.15486 |
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| author | Xuehan Gao Zhen Cao Xiayao Diao Jiaqi Zhang Ke Zhao Libing Yang Zhihong Qian Xiaoyun Zhou Chao Guo Yeye Chen Ziwen Liu Shanqing Li |
| author_facet | Xuehan Gao Zhen Cao Xiayao Diao Jiaqi Zhang Ke Zhao Libing Yang Zhihong Qian Xiaoyun Zhou Chao Guo Yeye Chen Ziwen Liu Shanqing Li |
| author_sort | Xuehan Gao |
| collection | DOAJ |
| description | Abstract Background Metastasis to the thyroid gland from lung adenocarcinoma is rare and challenging to diagnose due to similar histopathological features. This study aimed to analyze the clinicopathological characteristics of and treatment strategies for lung adenocarcinoma metastasis to the thyroid based on 11 years of institutional experience. Methods A retrospective study included patients with lung adenocarcinoma metastasis to the thyroid at our center from 2010 to 2023. Clinicopathological features and clinical outcomes were analyzed. Results Among 9714 lung adenocarcinoma patients, nine patients (five females, 55.6%) were diagnosed with thyroid metastasis, presenting primarily with cough symptoms. Most patients (88.9%) had synchronous tumors, whereas a minority (11.1%) had metachronous tumors. The median time from primary tumor diagnosis to metastasis was 4.8 months. Most patients developed bilateral thyroid metastases (88.9%). Diagnosis of thyroid metastasis was primarily through fine‐needle aspiration (FNA), with one case misdiagnosed as papillary thyroid carcinoma. Immunohistochemical staining revealed thyroid transcription factor‐1 (TTF‐1) and novel aspartic proteinase of pepsin family A (Napsin‐A) positivity and paired box 8 (PAX8) negativity. Genetic testing found epidermal growth factor receptor mutations in 71.4% of patients. The individualized comprehensive therapy included surgery, chemotherapy, immunotherapy, and targeted and supportive therapy. The median overall survival was 56.0 months, with a progression‐free survival of 12.7 months. Kaplan–Meier (K–M) analysis suggested improved survival with no advanced symptoms (p = 0.03) and targeted therapies (p = 0.05). Conclusions Lung adenocarcinoma metastasis to the thyroid is a rare disease, with an incidence of 0.1% among lung adenocarcinoma patients. Early treatment after symptom onset and personalized targeted therapies may improve prognosis. Despite rapid disease progression, favorable outcomes can be achieved with comprehensive treatment. |
| format | Article |
| id | doaj-art-d4f2ac8df9d04cbe907c444350dd8d22 |
| institution | Kabale University |
| issn | 1759-7706 1759-7714 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj-art-d4f2ac8df9d04cbe907c444350dd8d222025-01-15T16:00:32ZengWileyThoracic Cancer1759-77061759-77142025-01-01161n/an/a10.1111/1759-7714.15486Clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland: A single‐center, 11‐year experienceXuehan Gao0Zhen Cao1Xiayao Diao2Jiaqi Zhang3Ke Zhao4Libing Yang5Zhihong Qian6Xiaoyun Zhou7Chao Guo8Yeye Chen9Ziwen Liu10Shanqing Li11Department of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of General Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of General Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Thoracic Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaAbstract Background Metastasis to the thyroid gland from lung adenocarcinoma is rare and challenging to diagnose due to similar histopathological features. This study aimed to analyze the clinicopathological characteristics of and treatment strategies for lung adenocarcinoma metastasis to the thyroid based on 11 years of institutional experience. Methods A retrospective study included patients with lung adenocarcinoma metastasis to the thyroid at our center from 2010 to 2023. Clinicopathological features and clinical outcomes were analyzed. Results Among 9714 lung adenocarcinoma patients, nine patients (five females, 55.6%) were diagnosed with thyroid metastasis, presenting primarily with cough symptoms. Most patients (88.9%) had synchronous tumors, whereas a minority (11.1%) had metachronous tumors. The median time from primary tumor diagnosis to metastasis was 4.8 months. Most patients developed bilateral thyroid metastases (88.9%). Diagnosis of thyroid metastasis was primarily through fine‐needle aspiration (FNA), with one case misdiagnosed as papillary thyroid carcinoma. Immunohistochemical staining revealed thyroid transcription factor‐1 (TTF‐1) and novel aspartic proteinase of pepsin family A (Napsin‐A) positivity and paired box 8 (PAX8) negativity. Genetic testing found epidermal growth factor receptor mutations in 71.4% of patients. The individualized comprehensive therapy included surgery, chemotherapy, immunotherapy, and targeted and supportive therapy. The median overall survival was 56.0 months, with a progression‐free survival of 12.7 months. Kaplan–Meier (K–M) analysis suggested improved survival with no advanced symptoms (p = 0.03) and targeted therapies (p = 0.05). Conclusions Lung adenocarcinoma metastasis to the thyroid is a rare disease, with an incidence of 0.1% among lung adenocarcinoma patients. Early treatment after symptom onset and personalized targeted therapies may improve prognosis. Despite rapid disease progression, favorable outcomes can be achieved with comprehensive treatment.https://doi.org/10.1111/1759-7714.15486lung adenocarcinomametastasisoutcomespathologythyroid |
| spellingShingle | Xuehan Gao Zhen Cao Xiayao Diao Jiaqi Zhang Ke Zhao Libing Yang Zhihong Qian Xiaoyun Zhou Chao Guo Yeye Chen Ziwen Liu Shanqing Li Clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland: A single‐center, 11‐year experience Thoracic Cancer lung adenocarcinoma metastasis outcomes pathology thyroid |
| title | Clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland: A single‐center, 11‐year experience |
| title_full | Clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland: A single‐center, 11‐year experience |
| title_fullStr | Clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland: A single‐center, 11‐year experience |
| title_full_unstemmed | Clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland: A single‐center, 11‐year experience |
| title_short | Clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland: A single‐center, 11‐year experience |
| title_sort | clinicopathological features and outcomes of rare lung adenocarcinoma metastasis to the thyroid gland a single center 11 year experience |
| topic | lung adenocarcinoma metastasis outcomes pathology thyroid |
| url | https://doi.org/10.1111/1759-7714.15486 |
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